Search
Now showing items 1-10 of 14
Characterization of novel genes of importance for renal glomerular function and disease
(2013-05-02)
Glomerular kidney diseases are a major health care burden. The glomerular filtration barrier consists of three layers: the slit diaphragm that bridges the interlocking foot pro- cesses of the podocytes, the glomerular ...
Inflammation and cytokine production in experimental neuroinflammatory disorders
(2013-09-04)
Glutamate excitotoxicity is involved in the pathogenesis of a variety of neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS). Kainic acid (KA), an analogue ...
Modulation of nuclear receptor function by interacting proteins
(2007-08-21)
Nuclear receptors are a family of transcription factors involved in many
biological processes. They represent key potentials as therapeutic
targets for several clinical conditions such as diabetes, obesity,
cardiovascular ...
Peripheral nerve glia as multipotent progenitors in craniofacial development
(2014-12-22)
Craniofacial development is complex. Numerous populations of progenitor cells coordinate
activities to produce an array of highly integrated tissues inside the developing head.
However, it is not clear how some key ...
HIV-1 genotype and vertical transmission in northern Vietnam
(2008-10-28)
After 18 years from the beginning of the HIV-1/AIDS epidemic in Vietnam, the number of HIV-1 infected individuals is still increasing. Investigations conducted at two distinct time points in two separate groups of HIV-1 ...
Innate immunity in the immunopathogenesis of chronic viral infection
(2016-01-27)
Natural killer (NK) cells have a key role in control and clearance of viral infections. To carry
out this function NK cells are capable of recognising infected cells and responding with
induction of apoptosis in these ...
Expression and interaction studies of recombinant human monoclonal antibodies
(2007-03-02)
The highly specific binding characteristics of monoclonal antibodies
(mAbs) have made them one of the most useful tools in the fields of
research and biotechnology where they provide the basis for a large
number of ...
Topology and membrane rearrangements of the hepatitis C virus protein NS4B
(2006-09-15)
Hepatitis C virus (HCV) is a major cause of chronic liver disease and viral hepatitis around the world. Approximately 180 million people or 3% of the world's population are infected with the virus. The infection does only ...
Role of new podocyte-associated proteins in the renal ultrafiltration barrier
(2019-08-09)
Chronic kidney disease (CKD) is a major health problem and an economical burden affecting people worldwide. The main causes of CKD are diabetes and hypertension and patient numbers keep increasing. In many cases, CKD is ...
HPV genotyping and potential progression markers in cervical intraepithelial neoplasia : clinical and diagnostic impact
(2009-05-15)
The aim of this thesis is to identify clinically useful early molecular
markers to predict progression to carcinoma in women with preinvasive
lesions of the cervix, for the purpose of improving care of these women
and ...