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Peripheral nerve glia as multipotent progenitors in craniofacial development
(2014-12-22)
Craniofacial development is complex. Numerous populations of progenitor cells coordinate
activities to produce an array of highly integrated tissues inside the developing head.
However, it is not clear how some key ...
Cancer after bariatric surgery : risk and prognosis
(2019-09-13)
Obesity is a major public health challenge with a rapidly growing prevalence worldwide. The condition increases the risk of multiple diseases, including cancer in different locations. Current evidence on the effect of ...
Elevated fasting glucose levels in obese children and adolescents : prevalence and long-term consequences
(2016-01-29)
Background: Obesity in childhood and adolescents is a major concern in Sweden, as in many parts of the world. Already during the pediatric years is obesity associated with several metabolic complications, which often ...
The Alzheimer’s disease related gamma-secretase complex : localization and novel interacting proteins
(2010-05-07)
Alzheimer’s disease (AD) is caused by synaptic and neuronal loss in the
brain that eventually results in cognitive decline. Characteristic
hallmarks of AD are senile plaques containing the amyloid beta-peptide
(Abeta) ...
Identification and investigation of gamma-secretase associated proteins from brain
(2012-08-17)
Alzheimer disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. The pathological hallmarks in the AD brain are extracellular deposition of amyloid plaques, mainly composed of the ...
Etiology and early detection of pancreatic cancer
(2021-11-08)
Pancreatic cancer is one of the most dismal malignancies. Although its incidence and prevalence are relatively low, the disease burden is still an important health issue, especially in terms of mortality. Primary prevention ...
Molecular studies of the γ-secretase complex : focus on genetic and pharmacological modulation
(2012-09-13)
γ-Secretase is a multi-subunit protease complex, composed of presenilin (PS1 or PS2), Nicastrin, Pen-2 and Aph-1, which generates the Alzheimer disease (AD) related 30-43 amino acid long amyloid β-peptide (Aβ). The complex ...
Insulin resistance in children and adolescents : mechanisms and clinical effects
(2021-04-15)
Background: Insulin resistance is a condition in which insulin does not achieve appropriate response in different target tissues, it is associated with obesity and one of the main culprits in the development of type 2 ...