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Genetic and functional analysis of the adaptive immune response
(2023-02-01)
The cells of the adaptive immune system rely on somatic recombination of V, D and J genes to obtain a vast range of specificities. T cells use four chains encoded by three genomic loci, to produce alpha/beta or gamma/delta ...
Principles of transcriptional bursting in mammalian cells
(2023-05-22)
In mammalian cells, transcription occurs in discrete bursts leading to fluctuations in transcripts from expressed genes. Although this behavior was first reported not long after the discovery of messenger RNA (mRNA), the ...
Transcriptomic cellular diversity of the early human developing brain
(2023-01-27)
The complexity of the mammalian brain is partly reflected in its cell type diversity which influences the function of neurons that encode the behavior of animals. Brain cell type diversity emerges during embryonic stages, ...
Articular and epiphyseal cartilage : its formation, maintenance and repair
(2019-08-22)
Long bones develop via a series of ordered processes, initiated from mesenchymal stem cell condensation, cartilage anlagen formation, followed by central cell hypertrophy and vascular invasion and the finalized by the ...
Studies on genetic and epigenetic regulation of gene expression dynamics
(2023-03-10)
The information required to build an organism is contained in its genome and the first biochemical process that activates the genetic information stored in DNA is transcription. Cell type specific gene expression shapes ...
Deciphering cell motility and spatial sensing of intestinal cell types using an ex vivo intestinal model
(2023-10-02)
The intestine is a highly organized tissue with two distinct regions: the crypt and the
villus. When stem cells divide at the crypt bottom, half of their progeny migrates
upwards towards the villus, where they differentiate ...
Novel molecular techniques for diagnostics and cancer biology
(2022-11-25)
Molecular biology is reliant on a large set of increasingly complex methods. The development of high-throughput DNA sequencing almost 20 years ago kicked off a revolution in method development due to its incredible ...
Illuminating tissue organization by imaging the spatial transcriptome
(2022-12-19)
Our bodies consist of a large collection of cells that each have their own function in the organ that they reside in. The cells are grouped by functionality in cell types that arise during development as the result of the ...
Being present in caring encounters : a relational perspective on autonomy for older persons in municipal home help services
(2013-08-30)
The care of the old in Sweden and worldwide is developing towards an “aging in place.” Older people in Sweden are expected to remain in their own homes supported by municipal home help services. This development has entailed ...
Conformational dynamics in microRNAs : the example of miR-34a targeting Sirt1 mRNA
(2020-06-17)
In biology, regulatory mechanisms are essential to achieve complex tasks, as virtually every process can be positively or negatively modulated in its outcome, upon different cues. In humans, microRNAs (miRNAs) constitute ...