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Studies on genetic and epigenetic regulation of gene expression dynamics
(2023-03-10)
The information required to build an organism is contained in its genome and the first biochemical process that activates the genetic information stored in DNA is transcription. Cell type specific gene expression shapes ...
Cardiovascular disease in systemic lupus erythematosus
(2003-03-20)
Premature cardiovascular disease (CVD) is a major cause of morbidity and mortality in systemic lupus erythematosus (SLE). This is an important clinical problem and a main objective of this study was to identify risk factors ...
Sentinel node based immunotherapy of cancer
(2007-05-25)
The tumor draining lymph node, the sentinel node, is regarded as a valuable station for staging and evaluating prognoses for patients with cancer. The object of this thesis was to investigate the immune response against ...
Platelet angiogenic activities and their regulation on endothelial progenitor cell functions
(2015-08-12)
Platelets are essential for haemostasis and thrombosis, but also play a major role in angiogenesis. Activated platelets recruit progenitor cells and induce differentiation into endothelial progenitor cells (EPCs), which ...