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Principles of transcriptional bursting in mammalian cells
(2023-05-22)
In mammalian cells, transcription occurs in discrete bursts leading to fluctuations in transcripts from expressed genes. Although this behavior was first reported not long after the discovery of messenger RNA (mRNA), the ...
Use of analgesic drugs, occupational exposure to noise and solvents as risk factors for tinnitus and hearing impairment in a retrospective cohort study of male twins
(2016-03-10)
Background: Sweden has a unique twin registry administrated by Karolinska Institutet. A cohort of this register is the basis for this study. There are many causes of hearing loss and tinnitus, where genetics, diseases, ...
Studies on the gamma-secretase complex and processing of the Alzheimer's disease-associated amyloid precursor protein
(2004-03-26)
Alzheimer's disease (AD) is a devastating neurodegenerative disorder that
causes the most common form of dementia. Pathological lesions, such as
plaques consisting of the amyloid beta-peptide (Ab), are found in the
brains ...
Notch signaling : from receptor cleavage to chromatin remodeling
(2005-10-28)
One of the principal signaling mechanisms that control development of multicellular organisms is the Notch signaling pathway. The transmembrane Notch receptor, presented at the cell surface, interacts with ligand on ...