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Regulation of molecular processes in diffuse large B-cell lymphoma
(2013-04-25)
The molecular understanding of diseases has advanced rapidly due to the use of gene expression profiling. However, these methods have been hampered by the limitation to use frozen tissue specimens. Formalin fixation and ...
Studies of anemia in the myelodysplastic syndromes
(2008-08-15)
Background: The myelodysplastic syndromes (MDS) constitute a
heterogeneous group of malignant bone marrow disorders, characterized by
chronic anemia and increased risk of transformation to acute myeloid
leukemia (AML). ...
Quantitative MRI biomarkers of neurodegeneration in multiple sclerosis
(2022-02-28)
Background: Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease that targets myelin in the brain and spinal cord. The corpus callosum connects the cerebral hemispheres and is composed of ...
Tau and neurofilament proteins in Alzheimer’s disease and related cell models
(2007-11-23)
Background and aims: Among those afflicted with dementia more than half
suffer from Alzheimer’s disease (AD). Pathological hallmarks of the
disease include aggregates of Abeta, so called amyloid plaques, and
neurofibrillary ...
Roles of the transient receptor potential channels and the intracellular Ca2+ channels in Ca2+ signaling in the beta-cells
(2011-03-04)
Previous studies from our group reported that pancreatic β-cells express ryanodine receptors (RyRs) that can mediate Ca2+-induced Ca2+ release (CICR). The full consequences of the activation of RyRs on Ca2+ signaling in ...
Aberrant DNA methylation in acute myeloid leukemia
(2017-05-18)
DNA methylation is an important epigenetic mechanism that influences development and cancer by regulating gene transcription. Aberrant DNA methylation is a feature of cancer including acute myeloid leukemia (AML). It was ...