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Studies of anemia in the myelodysplastic syndromes
(2008-08-15)
Background: The myelodysplastic syndromes (MDS) constitute a
heterogeneous group of malignant bone marrow disorders, characterized by
chronic anemia and increased risk of transformation to acute myeloid
leukemia (AML). ...
Amyloid imaging in Alzheimer’s disease and mild cognitive impairment by positron emission tomography
(2008-09-19)
Effectiveness of future treatment strategies in Alzheimer s disease (AD)
will rely on early detection of disease and the possibility to clearly
evaluate their effects. The findings presented in this thesis concerns
both ...
Stimulating neuroprotective and regenerative mechanisms in Alzheimer disease
(2013-08-14)
The processes involved in neuroprotection and brain repair are an important aspect of the preservation and restoration of neuronal functions affected by pathological lesions. Mechanisms that stimulate, manage and regulate ...
Regenerating the brain : stem cell differentiation and cholinergic dysfunction in Alzheimer disease
(2014-05-15)
Hippocampal neurogenesis in the adult brain is important for learning and memory processes, which are heavily affected in Alzheimer disease (AD). Thus, targeting processes that could stimulate neurogenesis is a logical ...
Optimizing treatment : tumor markers and sclerotherapy in head and neck lesions
(2021-05-06)
Treatment of malignant and benign lesions in the head and neck area is challenging, due to complex anatomy and function. It is thus urgent to find ways to individualize treatment, in order to reduce side-effects, but with ...
Methods for studying memory B-cell immunity against malaria
(2020-05-15)
Plasmodium falciparum malaria remains one of the world’s deadliest infectious diseases and the search for an effective vaccine is highly warranted. Memory B cells (MBCs) and the antibodies they produce, once activated, is ...
Pathological responses of glial cells in spinal cord injury and rheumatoid arthritis
(2017-11-02)
Scientists have considered glia as mere passive allies of neurons for a long time. As a consequence, their functions have been greatly underestimated. Major discoveries made in the last three decades have changed our view ...
Innovative approaches to study basophil function in inflammation
(2017-10-16)
Basophils are circulating granulocytes. They are very rare and represent less than 1% of peripheral blood leukocytes. Basophils connect the innate and adaptive immune responses by the secretion of a variety of immune-mediators ...
Role of innate cellular immunity in the immunopathogenesis of HIV-1 infection in Uganda
(2016-11-17)
The global epidemic of HIV has resulted in more than 34 million deaths and currently 36.9 million HIV-infected people worldwide. Uganda has an HIV prevalence of 7.3%, equating to about 1.6 million people. This has placed ...
Mechanisms of Wnt signaling : from embryonic stem cells to dopaminergic neurons
(2011-01-19)
The ability of a cell to respond in a specific way to certain signals represents key biological phenomena governing development of multicellular organism. Cellular signaling regulates all aspects of cell biology such as ...