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Genetic and cognitive aspects on recovery after propofol anaesthesia
(2015-01-14)
Propofol is one of the most used intravenous anaesthetics in the western world. It is often
used for ambulatory surgery due to favourable pharmacokinetic properties allowing quick
onset and short emergence time. However, ...
Amyloid precursor protein : cellular studies and animal models
(2006-09-12)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by a number of neuropathological features, including extracellular deposits composed primarily of amyloid-β (Aβ) peptides. Aβ is derived ...
Angiogenesis modulates obesity and insulin sensitivity
(2014-12-17)
Both white and brown fat are highly vascularized tissues and vascular functions in adipose tissues remain largely unknown. In this thesis work, we aimed to study blood vessels in modulation of adipose tissue functions under ...
Etiology and early detection of pancreatic cancer
(2021-11-08)
Pancreatic cancer is one of the most dismal malignancies. Although its incidence and prevalence are relatively low, the disease burden is still an important health issue, especially in terms of mortality. Primary prevention ...
Obesity in childhood : psychosocial consequences and premature mortality
(2020-10-21)
Background: It is estimated that 91 million children worldwide will have obesity by 2025. Obesity in childhood is associated with increased risk of obesity in adulthood, psychosocial maladjustment, mental health problems, ...
Immune dysregulation in early life and risk of autism
(2022-11-15)
Background: The notion of immune perturbations in autism is in part based on numerous observations of an association between maternal infections in general during pregnancy and autism in the child, and on observations of ...
Studies on the role of SOCS3 and STAT3 in development and function of the immune system
(2017-11-27)
The immune system is composed of an innate and an adaptive response that protects us from the microbial attacks. The innate system provides a fast defense against infection. However, many microbes evade or overwhelm the ...
Signal integration between notch and hypoxia : insights into development and disease
(2007-01-26)
Oxygen is essentially required for aerobic metabolism in most eukaryotic
organisms. Therefore, it is striking that a number of tissues develop,
and are maintained at low oxygen (hypoxic) conditions in the body. For
instance, ...
Causes and consequences of temporomandibular joint diseases
(2023-05-22)
Temporomandibular joint disorders (TMJD), a subgroup of Temporomandibular disorders (TMD), has a multifactorial etiology with still largely unknown pathophysiology. Although many risk factors have been proposed, few ...
Characterization of non-coding RNAs in cancer
(2014-08-25)
While originally though to only code for proteins, it now stands clear that RNA is a multifunctional molecule involved in a great variety of molecular processes. Recent advances in genome-wide platforms have revealed ...