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Cardiovascular disease in systemic sclerosis
(2014-03-21)
Systemic Sclerosis (SSc) is an autoimmune rheumatic disease, characterized by fibrosis of the skin and internal organs, vasculopathy and the production of autoantibodies. Cardiac and pulmonary disease manifestations are ...
HMGB1 in inflammation : secretion and function
(2008-11-07)
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised
by progressive joint destruction. The inflammatory and joint destructive
processes in RA are mediated by resident synovial cells and cells
recruited ...
Apoptosis, cellular division or mitotic catastrophe? Effects of kinase inhibition and DNa damage in lung cancer cells
(2007-01-07)
Non-small cell lung cancer (NSCLC) cells are generally characterized by a
low response to conventional anti-cancer agents, such as DNA-damaging
drugs. Treatments that induce DNA damage relies on cellular signalling
resulting ...
Parental characteristics and offspring internalizing behaviors : understanding the associations using quantitative genetics
(2013-12-19)
Internalizing problems increase dramatically from childhood to adolescence and account for a large proportion of mental health problems worldwide. During the past decade research has documented a robust association between ...
Intellectual disability in a forensic psychiatric setting
(2023-08-15)
The main focus of this thesis was to increase knowledge of offenders with ID in forensic psychiatric settings. Offenders with ID constitute a subgroup of offenders, and they have played a peripheral role in previous research ...
Decoding the contribution of transcription factors to cell fate determination
(2018-11-19)
It is well accepted that transcription factors (TFs) play a crucial role in determining cell identity. Although RNA expression or protein abundance data show that a large fraction of the total TFs are expressed in a given ...
Sensorimotor reorganization in relation to hand function following unilateral brain lesions
(2012-05-18)
Most activities of daily living require skillful use of our hands. Whatever the complexity of the task, our ability to perform any motor function largely relies on the integrity of the widely distributed corticomotor ...