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Functional study of nuclear receptors and bile acids in the modulation of cholesterol homeostasis
(2013-10-08)
Cholesterol carries multiple biological functions in the body, and imbalanced cholesterol metabolism leads to atherosclerosis and cardiovascular diseases. The present thesis aims to extend the knowledge of cholesterol ...
Famine in Nigeria and vitamin D in Sweden : two early life exposures and their relation to cardiovascular risk in adulthood
(2013-12-18)
Early life environment has in previous research been linked to risk of disease in adulthood. This thesis investigated three types of early life exposures and their potential associations with adult life cardiovascular risk. ...
Identification of novel Wnt/PCP signaling regulators and their role in midbrain dopaminergic neuron development and Parkinson's disease
(2018-03-08)
Wnt signaling controls a wide spectrum of complex cell responses during prenatal development, in the adulthood and during disease. In this doctoral study, we have identified and explored novel regulatory components of ...