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Neurological complications after stem cell transplantation in children
(2011-05-26)
Allogeneic haematopoietic stem cell transplantation (HSCT) is a well established method used in the treatment of a number of benign and malignant blood diseases, inborn errors of metabolism and severe congenital immunodeficiency ...
Transcriptional regulation of ribosomal RNA gene : actin, myosin and beyond
(2014-05-22)
In the eukaryotic cell nucleus, actin and nuclear myosin 1c (NM1) are key regulators of RNA
polymerase I (Pol I) transcription and function across the entire ribosomal RNA biogenesis
pathway. At the gene level, actin ...
The association between hormonal/reproductive factors and the risk of developing rheumatoid arthritis
(2015-11-25)
Rheumatoid arthritis (RA) is a chronic inflammatory disease which leads to joint damage and bone destruction, with a complex interplay of genetic and environmental factors involved in its etiology. RA is more common among ...
The role of EBNA binding proteins in cell transformation
(2013-05-06)
Epstein-Barr virus (EBV) infects majority of the human population and maintains sub-clinical infection. However, under certain conditions it is associated with several B-cell malignancies, such as Burkitt lymphoma, Hodgkin’s ...
Regulation of molecular processes in diffuse large B-cell lymphoma
(2013-04-25)
The molecular understanding of diseases has advanced rapidly due to the use of gene expression profiling. However, these methods have been hampered by the limitation to use frozen tissue specimens. Formalin fixation and ...