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Studies of the device perfect capsule in an animal model to reduce lens epithelial cell proliferation
(2008-09-12)
The sealed-capsule irrigation device, the Perfect Capsule, is a surgical
device designed to target lens epithelial cells (LECs) during cataract
surgery and prevent posterior capsule opacification (PCO). This is
especially ...
Pathogenesis of an emerging pathogen : Crimean-Congo hemorrhagic fever virus
(2010-12-08)
Epithelial cells represent the first barrier to viral infection and the site of viral entry and release is often intimately connected with viral spread and pathogenesis. The plasma membrane of epithelial cells is polarized ...
Ephrin and Eph-receptor growth factor signaling in non small cell lung cancer : identification of biomarkers and therapeutic targets
(2016-04-29)
Non-small cell lung cancer (NSCLC) is the main subtype of lung cancer (LC) and unfortunately it responds very poorly to conventional chemo- and radiotherapy (RT). Moreover, NSCLC is often diagnosed at a stage where metastases ...
Access to health care for febrile children in Uganda : symptom recognition, care seeking practices and provider choice
(2009-05-18)
Background: Febrile illnesses including malaria and pneumonia are leading
causes of death among children under five in Uganda. The survival of a
sick child depends on access to prompt and appropriate care. Despite
government ...
Managing children with pneumonia symptoms in malaria endemic Uganda
(2008-12-23)
Background: Pneumonia is one of the leading killers of children under
five years of age. In sub-Saharan Africa, symptoms of pneumonia often
overlap with those of malaria. While many countries have made public
commitments ...
HMGB1 in inflammation : secretion and function
(2008-11-07)
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised
by progressive joint destruction. The inflammatory and joint destructive
processes in RA are mediated by resident synovial cells and cells
recruited ...
Characterization of malignant pleural mesothelioma : possibilities for an individualized therapeutic arsenal
(2014-01-28)
Less than 50% of malignant mesothelioma patients respond to standard chemotherapy treatment and there is a great need to identify these patients, and find their best treatment options. The aim of this thesis was to increase ...
Aetiology and infection susceptibility in neutropaenic patients
(2012-04-13)
Increasingly intensive antineoplastic regimes have been effective in the treatment for haematological malignancies, but as effective as it is in limiting neoplasm of the malignant cells, bystander damage occurs equally to ...
Etiology and early detection of pancreatic cancer
(2021-11-08)
Pancreatic cancer is one of the most dismal malignancies. Although its incidence and prevalence are relatively low, the disease burden is still an important health issue, especially in terms of mortality. Primary prevention ...
From health outcomes to value assessments : preference-based evaluation of interventions and valuation of productivity costs among working adults
(2017-08-28)
Background: This thesis applies value assessment frameworks to non-specific low back pain (LBP) in a working population to evaluate health outcomes and to estimate productivity costs. LBP is a common diagnosis in primary ...