Search
Now showing items 1-10 of 10
Body site of cutaneous malignant melanoma : primary tumor location in relation to phenotypic and prognostic factors
(2002-11-08)
The main purpose of this thesis was to analyze the primary body site of cutaneous malignant melanoma (CMM) in relation to phenotypic traits and prognosis. It is clear that several characteristics of CMM are different, and ...
Understanding structure and function of membrane protein transporters
(2008-11-28)
Membrane protein transporters are important proteins in the cell, as they maintain different solutes and metabolites at a stable concentration. Numerous diseases can be linked to malfunctioning transporters, which makes ...
Studies on arachidonic acid metabolism in normal and malignant hematopoietic cells
(2010-01-15)
This thesis deals with the metabolism of arachidonic acid via the 5-lipoxygenase- and the 15-lipoxygenase-1 pathways in normal and malignant hematopoietic cells.
The first part of the thesis (papers I & II) describes ...
BRICHOS interactions with amyloid proteins and implications for Alzheimer disease
(2016-10-05)
To date, about 30 diseases, in which amyloid fibrils form extracellular deposits, have been identified in humans. It is not known if the fibrils have a function, like storage of misfolded proteins, or if they just reflect ...
Functional characterization of the alternative reading frame protein p14ARF
(2004-05-06)
A deeper understanding of the molecular events underlying tumor development is a prerequisite for the design of novel and efficient therapies. Inactivation of the p53 and retinoblastoma (Rb) tumor suppressor pathways appears ...
New potential targets in medulloblastoma therapy : studies on cellular mechanisms and mediators
(2010-01-15)
Medulloblastoma is an embryonal tumour that mainly affects children. It
is the most common malignant brain tumour in children and accounts for
15% of all childhood brain tumours. It most often presents in the
cerebellum ...
Attempted suicide in Vietnam
(2006-10-05)
Suicide and attempted suicide is currently a major public health problem in rapidly developing countries but there are limited studies on this field in Asian countries. These are the first studies on suicidal behavior in ...
Assessment of environmental contaminants’ neurotoxicity : in vitro and in vivo experimental studies
(2012-11-27)
Accumulating evidence points to environmental contaminants as possible causes of neuronal damage in developing organisms. A prerequisite to prevention is the recognition of a chemical’s harmful effects during development. ...
Respiratory mononuclear phagocytes during steady state and sarcoidosis
(2020-08-25)
Each day, our lungs inhale thousands of liters of air containing not only essential oxygen but also smoke particles, dust, allergens, and potentially dangerous pathogens. In order to tolerate harmless antigens and initiate ...
Antireflux surgery in the prevention of supra-esophageal cancer and mortality
(2021-03-02)
Gastroesophageal reflux disease (GERD), mainly characterized by heartburn or regurgitation, is a common condition in the Western world with an increasing prevalence. GERD is associated with an increased risk of adenocarcinoma ...