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Now showing items 1-10 of 16
Cytokines in rheumatoid arthritis
(2000-01-21)
Rheumatoid arthritis (RA) is a chronic systemic disease characterised by inflammation in several joints. Cytokines appear to be important as both disease promoting and disease- suppressing mediators in the disease. The use ...
Stretching the genetic code : incorporation of selenocysteine at specific UGA codons in recombinant proteins produced in Escherichia coli
(2008-11-07)
Selenocysteine (Sec) exists in all domains of life and represents the
21st naturally occurring amino acid. A Sec residue is co-translationally
incorporated at a predefined opal (UGA) codon. UGA codons normally encode
for ...
Networks in epigenetics
(2010-04-15)
Networks are ubiquitous. It is only recently, we started exploring what purpose they serve in real world. Biological research supposedly has, and will be, benefited most from the network science because of inherent complexity ...
Molecular mechanisms in idiopathic inflammatory myopathies
(2014-09-19)
Background: Myositis is a group of rare autoimmune diseases. Muscle weakness and fatigue
are the dominant symptoms and inflammation with T cells and macrophages is a
characteristic finding in muscle tissue. ...
Acute intermittent porphyria : studies of chronic disease, recombinant enzyme therapy and late complications
(2008-10-17)
This thesis comprise five studies on patients with acute intermittent porphyria (AIP) observed under different clinical conditions associated with the disorder. They have generally been monitored at the porphyria out-patient ...
Recessive parkinsonism, mitochondria and translational regulation
(2008-09-05)
Three genes are known to cause recessive forms of Parkinson disease (PD) in humans: parkin, PINK1 and DJ-1. Of these, the rarest is DJ-1; less than fifty known cases worldwide are due to mutations in DJ-1. Though rare, ...
Short and long term effects of bacterial gastrointestinal infection
(2008-05-09)
The objectives of this thesis were to increase our understanding of the
mortality and complications associated with bacterial gastrointestinal
infections, with focus on Salmonella and Campylobacter enteritis. The
effect ...
Human herpesvirus-6 in multiple sclerosis : assay development, immune responses and host genetics
(2013-11-14)
MS is a chronic inflammatory demyelinating disease of the CNS that implies impaired motor- and cognitive functions. Life expectancy is not severely affected but the disease has substantial negative effects on the quality ...
Health economics of depression
(2006-09-22)
Health economics deals with how resources are used for health production and how they should be most efficiently allocated to maximise health outcomes. Many treatment alternatives for depression are currently available, ...
Risks and benefits of drinking water treatment : focusing on child health and prenatal development
(2021-02-24)
Drinking water is our most important food item and its access is indispensable for a wellfunctioning society. Recent Swedish water-borne outbreaks have demonstrated a system vulnerability and a clear need for improved ...