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Epidemiological studies of Helicobacter pylori and its relation to cancer and precancerous lesions in the upper gastrointestinal tract
(2004-05-21)
Helicobacter pylori infection is strongly associated with gastric cancer risk. The carcinogenic process is supposed to occur step by step, from a normal gastric epithelium via gastritis, atrophy, intestinal metaplasia to ...
Humming, nitric oxide and paranasal sinus ventilation
(2006-04-21)
The paranasal sinuses are air-filled bony cavities surrounding the nose. They communicate with the nose via the sinus ostia through which fluid and gases pass in both directions. A proper ventilation is crucial for sinus ...
Antibiotic resistance and antibiotic consumption with focus on Escherichia coli and Pseudomonas aeruginosa
(2007-05-04)
Aims: The general aims of the present studies were to assess the levels of antibiotic resistance, in relation to antibiotic consumption at the Karolinska University Hospital, Solna (KS) and at 11 other Swedish hospitals, ...
On the role of different signal transduction pathways in induction of apoptosis by anticancer drugs
(2007-04-13)
Anticancer drug treatment gives rise to complex cellular responses in
tumor cells. An improved understanding of the mechanisms underlying these
responses is important in order to improve treatment. It is also of
importance ...
Genetic and epigenetic mechanisms in primary hyperparathyroidism
(2012-12-10)
Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by abnormally excessive secretion of parathyroid hormone (PTH) and elevated serum calcium. PHPT patients can develop a wide range of complications ...
Hypospadias : gene mapping and candidate gene studied
(2009-08-28)
Hypospadias is a common congenital malformation in boys, characterized by incomplete fusion of the urethral folds, abnormal opening of urethra and different degrees of curvature of the penis. In Sweden, the incidence of ...
Low-dose methadone as add-on to ongoing opioid treatment in cancer-related pain
(2020-11-17)
Background: In complex cancer-related pain in imminently dying patients, even high doses of ordinary opioids may have an insufficient effect. The addition of low-dose methadone to another ongoing opioid has been proposed ...
Identification of genes that regulate arthritis and IgE production in rat and human
(2005-08-08)
Multiple genome-wide scans have identified quantitative trait loci (QTLs) that influence inflammatory diseases on chromosome 4q42 in DA rats. Several of the QTLs overlap with the QTL designated Oia2 (Oil-induced arthritis-2), ...
Health-related quality of life after oesophageal cancer surgery for prediction of morbidity and mortality
(2010-10-01)
This thesis investigates the health-related quality of life (HRQL) among surgically treated oesophageal cancer patients. The established curative treatment for oesophageal cancer is extensive surgery with a high risk of ...
Drug use in institutionalized and home-dwelling elderly persons
(2012-05-15)
The overall aim of this thesis is to investigate drug use in institutionalized and home- dwelling elderly, with a special focus on dementia. The major findings from the separate studies are summarized below.
Study ...