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Genetic and epigenetic mechanisms in primary hyperparathyroidism
(2012-12-10)
Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by abnormally excessive secretion of parathyroid hormone (PTH) and elevated serum calcium. PHPT patients can develop a wide range of complications ...
Potential novel molecular targets for breast cancer diagnosis and treatment
(2016-09-09)
Breast cancer possesses the highest incidence among cancers in women worldwide,
accounting for approximately 26% of all cancers in women. Due to the discovery of specific
predictive and prognostic biomarkers, breast ...
Renal function decline and optimized planning for kidney replacement therapy
(2022-05-18)
Chronic Kidney disease (CKD) is an increasing health problem world-wide, and the prevalence increases with age. CKD is a life-threatening condition, with high risk of cardiovascular disease and mortality. Patients with ...
Screening for diabetic retinopathy : aspects of photographic methods
(2005-10-14)
Diabetic retinopathy (DRP) is a major cause of acquired blindness and visual impairment among people of working age as well as those aged 65 years or more. About 3-4% of the population has diabetes mellitus, 35-65% of the ...
Adjuvant hormone therapy in breast cancer patients : a special focus on treatment discontinuation
(2023-04-19)
Purpose: Breast cancer is the most common cancer among women, with approximately 80% of cases being estrogen-receptor (ER) positive. Adjuvant hormone therapy is a standard treatment that is recommended for ER-positive ...
Immunological alterations, therapies with immune check-point inhibitors and beyond in patients with metastatic melanoma
(2020-10-07)
In the last decade the treatment of metastatic melanoma (MM) has been revolutionized and changed the life of many patients, offering prolonged survival and improved symptom control. These treatment strategies have also ...
Fighting cardiometabolic disease : validation of new experimental models and therapeutic targets
(2020-05-14)
The prevalence of cardiometabolic diseases (CMD) such as atherosclerotic cardiovascular diseases, type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD), has grown dramatically during the last decades. Hence, ...