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Epidemiological studies of Helicobacter pylori and its relation to cancer and precancerous lesions in the upper gastrointestinal tract
(2004-05-21)
Helicobacter pylori infection is strongly associated with gastric cancer risk. The carcinogenic process is supposed to occur step by step, from a normal gastric epithelium via gastritis, atrophy, intestinal metaplasia to ...
Structural-functional studies of mitochondrial matrix proteins
(2018-11-01)
The mitochondrion is the powerhouse of the eukaryotic cell. Most of the energy required to carry out cellular processes is generated inside mitochondria via the process of oxidative phosphorylation. The machinery required ...
Cerebral microbleeds and cognitive impairment
(2016-08-12)
Background: With increasingly ageing populations comes an increased prevalence of cognitive impairment and dementia. The pathophysiology behind dementia is still unknown, and there is no cure. Microscopic bleeds in the ...
Airway smooth muscle as a target in asthma : new insights into bronchorelaxation and hyperreactivity
(2015-05-08)
Patients with asthma suffer from reversible airway obstruction accompanied by airway hyperresponsiveness (AHR). Airway smooth muscle (ASM) is central to bronchoconstriction and AHR and is therefore the target of existing ...
Effects of excess glucocorticoids on neural cell fate : long lasting consequences of adverse prenatal factors
(2017-10-02)
The developing nervous system is particularly vulnerable to high level of glucocorticoids (GCs). Excess GCs is often associated with decreased birth weight in relation to gestational age, and to increased risk of psychiatric ...