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Stimulating neuroprotective and regenerative mechanisms in Alzheimer disease
(2013-08-14)
The processes involved in neuroprotection and brain repair are an important aspect of the preservation and restoration of neuronal functions affected by pathological lesions. Mechanisms that stimulate, manage and regulate ...
Exploring the genomic and transcriptomic landscape of immune cells in multiple sclerosis : towards better biomarkers, diagnosis and treatment
(2020-02-07)
The overall aim of this thesis was to determine the changes in gene regulation taking place in immune cells during the course of Multiple Sclerosis. Over 200 MS-associated SNPs have been identified from GWAS studies. These ...
Follicular lymphoma : clinical and biological factors associated with response to therapy and overall prognosis
(2020-01-29)
Follicular lymphoma (FL) is a heterogeneous group of malignancies within the adaptive immune system. The clinical course is highly variable. Treatment includes different chemotherapy regimens as well as the anti-CD20 ...
Genetic vulnerability, environmental exposures and neurodevelopmental disorders : clinical insights and in-vitro consequences
(2023-08-25)
An understanding of how different genetic backgrounds and environmental exposures interact and contribute to diverse medical conditions like neurodevelopmental disorders (NDDs), is key to better health outcomes. A considerable ...
Genetic, magnetic resonance imaging and body fluid biomarker associations with severity of multiple sclerosis
(2023-08-29)
Multiple sclerosis is a chronic and progressive neuroinflammatory disease that leads to demyelination and neurodegeneration in the central nervous system (CNS). Previous research has identified a wide range of environmental, ...
Specific IgE-profiles and allergy prediction
(2022-09-22)
Presence of antibodies of type Immunoglobulin E (IgE-ab), often called sensitization, is common and often precede development of atopic disease, including food allergy. While not all IgE-sensitized individuals develop food ...
Autism : educational outcomes and self-harm in adolescents and young adults
(2022-11-23)
Autism is one of the most prevalent neurodevelopmental conditions worldwide, and autistic individuals face challenges in daily functioning related to differences and difficulties in social interaction and communication ...
An integrative systems biology study to understand immune aging in people living with HIV
(2023-05-10)
Antiretroviral therapy (ART) reduces viral replication, restores T helper cells and improves
the survival of people living with HIV (PWH), transforming a life-threatening disease into a
manageable chronic infection. ...
Healthcare when the bets are off : symptoms, trajectories and treatment of individuals with gambling disorder
(2023-03-28)
Gambling Disorder is a debilitating condition associated with several adverse outcomes.
Despite available treatment, most of those suffering never seek help and those that do
often present a complex clinical picture with ...
Understanding inflammation requires neuroscience
(2022-03-01)
Inflammation and its resolution are processes subject to neural regulation (1). The best-characterized immune-regulating reflex is the “inflammatory reflex”, in which the efferent branch of the vagus nerve plays a central ...