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Concepts in DNA immunization overcoming viral diversity and enhancing plasmid immunogenicity
(2004-05-07)
On April 23, 1984, the prominent scientist Robert Gallo held a historical press conference at the Department of Health and Human Services, Washington D.C., USA. He announced that his laboratory at the National Institutes ...
Studies on cholesterol homeostasis by modulation of lipoproteins and bile acids
(2010-01-08)
Excess plasma cholesterol, in particular high levels of LDL cholesterol, is a major risk factor for the development of atherosclerosis. The liver has a central role in the regulation of cholesterol metabolism: i) a major ...
Mechanistic insights into the biosynthesis of polyketide antibiotics
(2006-11-24)
Anthracyclines are a group of aromatic polyketide compounds with significant medical importance due to their antineoplastic properties. Doxorubicin and daunorubicin members of this family are among the two most commonly ...
Enzymatic activation of oxygen in the biosynthesis of polyketide antibiotics
(2009-09-04)
The electron structure of molecular oxygen (O2) is such that it cannot spontaneously react with organic molecules, a feature that protects organisms from oxidative stress. However, oxygenases can insert O2 in organic ...
Linker histone H1 and androgen receptor : two different players in the chromatin orchestra
(2012-05-23)
The linker histone H1 and the androgen receptor are two different players in the chromatin orchestra. The linker histone H1, one of the most abundant proteins in the nucleus, is located at the surface of the nucleosome but ...