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Protein expression in prostate cancer
(2006-01-06)
The molecular pathology of prostate cancer (PCa) is complex and the pathways and the acquired molecular defects responsible for PCa initiation, development and progression are still largely unknown. Tumors of the prostate ...
Regulation and function of thioredoxin reductase 1 in human tumor cells
(2009-05-22)
The thioredoxin system is a general protein disulfide reductase system
present in all organisms. Its function is to maintain an intracellular
reducing environment and upholding a defense against reactive oxygen
species ...
Functional characterization of cytosolic and mitochondrial thioredoxin reductases
(2006-09-15)
Mammalian thioredoxin reductases (TrxRs) are homodimeric selenoproteins belonging to the nucleotide oxidoreductase family. They contain a C-terminal penultimate selenocysteine residue, which is kept reduced by the N-terminal ...
Exploring thioredoxin reductase as an anticancer drug target
(2009-09-18)
Mammalian thioredoxin reductase (TrxR; EC 1.8.1.9) is a homodimeric NADPH-dependent selenium-containing flavoenzyme with disulfide oxidoreductase activity. The mammalian thioredoxin (Trx) system exerts an impressive spectrum ...
Intricate aspects of the thioredoxin system in redox signaling
(2014-05-02)
Reversible modifications of redox sensitive protein thiols by reactive oxygen and nitrogen species have emerged as a major posttranslational mechanism that affects the function of the respective proteins and therewith all ...