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Regulation and function of thioredoxin reductase 1 in human tumor cells
(2009-05-22)
The thioredoxin system is a general protein disulfide reductase system
present in all organisms. Its function is to maintain an intracellular
reducing environment and upholding a defense against reactive oxygen
species ...
Alzheimer disease associated Abeta and gamma-secretase : mitochondrial localization and involvement in cell death
(2009-01-30)
In several neurodegenerative disorders, including Alzheimer disease (AD)
and Parkinson disease (PD), protein aggregation is accompanied by
mitochondrial dysfunction. An increasing number of proteins found in
mitochondria ...
Studies on the gamma-secretase complex and processing of the Alzheimer's disease-associated amyloid precursor protein
(2004-03-26)
Alzheimer's disease (AD) is a devastating neurodegenerative disorder that
causes the most common form of dementia. Pathological lesions, such as
plaques consisting of the amyloid beta-peptide (Ab), are found in the
brains ...
The Alzheimer’s disease related gamma-secretase complex : localization and novel interacting proteins
(2010-05-07)
Alzheimer’s disease (AD) is caused by synaptic and neuronal loss in the
brain that eventually results in cognitive decline. Characteristic
hallmarks of AD are senile plaques containing the amyloid beta-peptide
(Abeta) ...