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Regulation of the hepatic ACAT2 expression and roles of HNF1alhpa and HNF4alpha in cholesterol metabolism
(2009-11-06)
Acyl-Coenzyme A:cholesterol acyltransferases (ACATs) 1 and 2 are integral membrane proteins located in rough endoplasmatic reticulum that catalyzes the formation of cholesteryl esters (CEs) from cholesterol and long-chain ...
A study on the E3 ligase TRIM21/Ro52
(2008-01-04)
Patients with the systemic autoimmune diseases Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE), often have antibodies against the intracellular protein TRIM21/Ro52. Although the presence of anti-TRIM21/Ro52 ...
Quantitative echocardiographic methods for patients with acute coronary syndrome
(2014-07-09)
Background: The aim of this thesis was to evaluate two diagnostic and two prognostic quantitative echocardiographic methods for patients with acute coronary syndrome (ACS).
Methods:
Velocity tracking (VeT) presents ...
Liquid chromatography : mass spectrometry study of two biochemical alcohol markers
(2007-03-09)
The interest in biochemical alcohol markers for detecting acute and
chronic alcohol consumption has expanded greatly during recent years. The
development and application of laboratory tests identifying early
problematic ...
Cytokine-modulated dendritic cell immunotherapy in autoimmune diseases
(2005-01-14)
Autoimmunity is the result of failure of self-tolerance processes. When the immune system fails to differentiate self from foreign, the effector mechanisms are directed towards the individual s own tissues, and pathological ...
Genetic and immunological control of human myasthenia gravis
(2005-09-23)
Myasthenia gravis (MG) is a classical autoimmune disease characterized by muscle weakness due to an immune attack against the nicotinic acetylcholine receptor (AChR) on the post-synaptic membrane of the neuromuscular ...
BRICHOS interactions with amyloid proteins and implications for Alzheimer disease
(2016-10-05)
To date, about 30 diseases, in which amyloid fibrils form extracellular deposits, have been identified in humans. It is not known if the fibrils have a function, like storage of misfolded proteins, or if they just reflect ...
Tumor acidosis in malignant progression and therapy
(2016-04-06)
Cancer still represents one of the leading causes of death despite the advances achieved during the past years. Improving the outcome of cancer patients requires the identification of more affective therapeutic strategies ...
Low-dose methadone as add-on to ongoing opioid treatment in cancer-related pain
(2020-11-17)
Background: In complex cancer-related pain in imminently dying patients, even high doses of ordinary opioids may have an insufficient effect. The addition of low-dose methadone to another ongoing opioid has been proposed ...
Platelet angiogenic activities and their regulation on endothelial progenitor cell functions
(2015-08-12)
Platelets are essential for haemostasis and thrombosis, but also play a major role in angiogenesis. Activated platelets recruit progenitor cells and induce differentiation into endothelial progenitor cells (EPCs), which ...