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Molecular dissection of pathways regulating glucose and lipid metabolism using siRNA
(2009-09-04)
Type 2 diabetes is a complex chronic disease that is associated with skeletal muscle insulin resistance. The aim of this thesis is to investigate pathways regulating glucose and lipid metabolism in human skeletal ...
Characterization of the mechanisms of action of anticancer agents in vitro and monitoring their effects in vivo
(2005-02-25)
Chemotherapeutic drug resistance is a major clinical problem and cause for failure in the therapy of human cancer. Mutations in apoptotic programs may promote tumour progression and reduce the efficacy of cancer therapy. ...
Neuroblastoma as a target for effector mechanisms of the immune system
(2007-05-24)
Neuroblastoma (NB) is the most common solid extracranial tumor in
children. Despite intensive multimodal treatment, the prognosis for
high-risk NB patients remains poor and therefore new treatment modalities
are needed. ...