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Insulin signaling and glucose transport in insulin resistant human skeletal muscle
(2005-08-19)
Insulin resistance in skeletal muscle is a hallmark feature of Type 2 diabetes mellitus. The overall aim of this thesis was to investigate downstream intermediates in the insulin signaling pathway in an attempt to characterize ...
Tick-borne encephalitis : clinical and pathogenetic aspects
(2015-11-25)
The aims of this study were to investigate the morbidity associated with tick-borne encephalitis (TBE) in the acute stage and at long-term follow-up, to identify the possible host risk factors for development of clinical ...
Enzymatic studies of alcohol dehydrogenase by a combination of in vitro and in silico methods
(2009-09-04)
The family of alcohol dehydrogenases (ADHs) catalyzes conversions of alcohols, ketons and aldehydes. The early discovery and isolation of ADH (1937) was followed by numerous investigations. It was also the first dimeric ...
Kinase cascades in the regulation of glucose homeostasis
(2005-03-09)
Therapeutic strategies to treat Type 2 Diabetes Mellitus (T2DM) aim at
improving muscle insulin sensitivity by either directly modulating, or
bypassing defective insulin signaling. Insulin induces metabolic and ...