Search
Now showing items 1-10 of 20
Transcriptional regulation by the nuclear receptors steroidogenic factor-1 and liver receptor homologue-1
(2011-01-24)
Steroidogenic Factor-1 (SF-1) and Liver Receptor Homologue-1 (LRH-1) are transcription factors belonging to the nuclear receptor (NR) family. In the adrenal cortex and gonads, SF-1 governs the expression of multiple enzymes ...
Endothelial function in isolated small arteries from women at reproductive age and after menopause : possibilities for improvement
(2003-10-24)
Background: Alterations in vascular function are present in patients with Preeclampsia (PE) and in women after menopause. PE is a syndrome peculiar to human pregnancy that adversely affects the mother by endothelial ...
Magnetic resonance imaging in the evaluation of chronic Achilles tendinosis
(2015-05-06)
The aim of the thesis was to evaluate magnetic resonance imaging (MRI) as an outcome in the evaluation of treatment in mid-portion Achilles tendinosis. Conventional MRI sequences, dynamic contrast enhanced MRI and measurement ...
Actin and myosin in transcription and chromatin regulation
(2016-05-02)
In mammalian cells, actin and myosin have emerged as regulators of nuclear structure and function, involved in chromatin remodeling and histone modifications, and in different phases of gene transcription. Actin and myosin ...
The secret life of nuclear IGF-1R : functions beyond traditional signaling pathways
(2014-09-26)
The implications of IGF-1R in normal development and disease are well established. IGF-1R plays pivotal roles in cell proliferation and cell survival and aberrant activation result in tumorigenesis and cancer progression. ...
Functional study of nuclear receptors and bile acids in the modulation of cholesterol homeostasis
(2013-10-08)
Cholesterol carries multiple biological functions in the body, and imbalanced cholesterol metabolism leads to atherosclerosis and cardiovascular diseases. The present thesis aims to extend the knowledge of cholesterol ...
Role of GPS2 in epigenome alterations linked to metaflammation
(2018-10-18)
Current evidence suggests that transcriptional and epigenomic reprogramming events, triggered by transcription factors and chromatin-modifying co-regulators, are of central importance for disease development. G-protein ...
Plasmid mediated antibiotic resistance : with focus on extended spectrum β-lactamases (ESBL)
(2013-10-02)
Enterobacteriaceae is a family of bacteria including Escherichia coli and Klebsiella pneumoniae that are common colonizers of the gastrointestinal tract. Extended spectrum β- lactamases (ESBL) are bacterial enzymes that ...
New insights of LXR signalling in inhibition of cancer proliferation and inflammation
(2016-04-18)
Liver X receptors (LXRs) are ligand-activated transcription factors belonging to the nuclear receptor (NR) superfamily. Up-to-date, more than 1900 publications have established the role of LXRs in cholesterol homeostasis, ...
Transcriptional and epigenetic regulation of gene expression by arsenic in cancer and normal cells
(2016-02-18)
Inorganic arsenic is a toxic metalloid that occurs naturally on the earth’s crust. Millions of people worldwide are exposed to inorganic arsenic via drinking water, and more recently also via contaminated food, in particular ...