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Myocardial angiogenesis induced by plasmid VEGF-A165 gene transfer : experimental and clinical studies
(2004-12-31)
New therapeutic options have emerged for patients with medically intractable angina who are not candidates for conventional revascularisation techniques, from increasing understanding of the biology of vessel formation and ...
Environmental factors and risk of acoustic neuroma
(2014-05-19)
The aim of this thesis was to increase the knowledge about environmental risk factors of acoustic neuroma and to increase the understanding of the methodological problems encountered when studying this tumor.
Acoustic ...
Cardiovascular effects of short-term exposure to air pollution : exploring potential pathways and susceptible subgroups
(2009-04-24)
Cardiovascular disease is the most common cause of mortality globally,
with a number of contributing risk factors. Ambient air pollution
represents a universally present risk factor with a substantial
preventive potential. ...
Effects of cigarettes, e-cigarettes and Swedish snus on vascular function
(2018-07-17)
Cigarette smoking is considered one of the leading causes of preventable morbidity and premature death worldwide. A large portion of this is attributable to cardiovascular disease such as ischemic heart disease and stroke. ...
Exploring the therapeutic effects of p53 modulation in cancer and immune cell biology
(2023-04-26)
The tumor suppressor protein p53 is dysregulated in almost all cancer. In around 50% of cancer p53 retains wild type activity but its inactivation by the E3 ligase MDM2 in a heterodimer complex with MDMX may be amplified, ...
Translational readthrough of nonsense mutant TP53, RB1 and PTEN tumor suppressor genes as a strategy for novel cancer therapy
(2023-03-09)
A nonsense mutation causes a premature termination codon in the coding sequence of an mRNA. This leads to termination of translation and release of a truncated and in most cases non-functional protein. Tumor suppressor ...