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Proximity in chromatin : opportunities for innovations
(2014-02-18)
Mammalian chromosomes extensively communicate with each other via long-range chromatin interactions. These interactions are mostly mediated by proteins, which work as teams to control genes in the cells. These interactions ...
Risk factors for rheumatoid arthritis : epidemiological studies of perinatal characteristics, infections and the inflammatory reflex
(2009-11-13)
Rheumatoid arthritis (RA) is a chronic inflammatory disease that is characterised by symmetric polyarthritis leading to progressive joint destruction. The aim of this thesis was to contribute to better knowledge of the ...
Epigenetic mechanisms of asthma and allergy
(2015-02-12)
Allergic diseases such as atopic eczema (AE) and asthma are chronic inflammatory disorders in which the regulation of the immune system is altered, in concert with disease-specific defects in target organs. Their inception ...
Leukotriene A4 hydrolase : identification of amino acid residues involved in catalyses and substrate-mediated inactivation
(2001-09-14)
Leukotriene (LT) A4 hydrolase catalyzes the committed step in the
biosynthesis of LTB4, a classical chemoattractant and immuine-modulating
lipid mediator involved in inflammation, host-defense against infections,
and ...
Population and single-cell analysis of human cardiogenesis reveals unique LGR5 ventricular progenitors in embryonic outflow tract
(2021-02-15)
The morphogenetic process of mammalian cardiac development is complex and highly regulated spatiotemporally by multipotent cardiac stem/progenitor cells (CPCs). Mouse studies have been informative for understanding mammalian ...
Deuterium-L-DOPA : a novel means to improve treatment of Parkinson's disease
(2012-08-31)
L-DOPA, the precursor of dopamine, is administered to restore dopamine deficiency in Parkinson´s disease (PD) patients. L-DOPA initially provides a sustained symptomatic relief with superior efficacy as compared to other ...
Aspects of low anterior resection syndrome : prevalence, risk factors and treatment
(2022-03-29)
After sphincter sparing rectal cancer surgery an impaired bowel function, i.e. Low Anterior Resection Syndrome (LARS), is common. The symptoms included in LARS are incontinence for flatus and/or feces, urgency, fragmentation ...