Search
Now showing items 1-10 of 17
Proximity in chromatin : opportunities for innovations
(2014-02-18)
Mammalian chromosomes extensively communicate with each other via long-range chromatin interactions. These interactions are mostly mediated by proteins, which work as teams to control genes in the cells. These interactions ...
Diabetes, physical activity and endometrial cancer
(2006-11-22)
Accumulating evidence suggests that hyperinsulinemia, in the context of insulin resistance, is associated with carcinogenesis. Physical activity is involved in the regulation of metabolic and hormonal pathways and is an ...
Molecular diagnosis of infection with Toxoplasma gondii in immunocompromised patients
(2006-08-23)
The protozoan parasite Toxoplasma gondii infects more than a billion people worldwide. The parasite is generally divided into three clonal lineages, denoted type I, II and III. Primary infections in humans are usually ...
Principles of transcriptional bursting in mammalian cells
(2023-05-22)
In mammalian cells, transcription occurs in discrete bursts leading to fluctuations in transcripts from expressed genes. Although this behavior was first reported not long after the discovery of messenger RNA (mRNA), the ...
Expression and regulation of antimicrobial peptides in mucosal immunity
(2012-10-25)
Antimicrobial polypeptides (AMPs) are effector molecules of the innate immune defense. AMPs are mainly expressed in epithelial cells and immune cells, providing the first line of defense to infection as direct antimicrobials. ...
Epiphora : impact on vision, outcome of lacrimal surgery and investigations with ultra-high-frequency ultrasound
(2021-04-08)
Epiphora is a common condition that often receives little attention. Excessive tear production creates an irregular and ever-changing ocular surface, affecting refraction and reducing vision. However, in a standard test ...
Traumatic patellar dislocation in childhood : late effects on knee function and cartilage quality
(2016-02-24)
Background and aim: Acute patellar dislocation affects approximately 1:1000 healthy children 9-
15 years of age, and up to 50% are at risk for recurrent dislocations. In adults the condition is
associated with long-term ...
The diverse role of laminin isoforms in neuronal cells, human mast cells and blood platelets
(2007-02-02)
The close interaction of cells with other cells and with extracellular
matrix (ECM) components is a prerequisite in a number of biological
activities. During development of the nervous system, axons often
navigate a ...
Hypoxic ischemic encephalopathy : diagnosis, hypothermia treatment and outcome
(2010-04-30)
Hypothermia treatment (HT) is now proven to be neuroprotective, is
associated with favourable outcomes, and is considered as the standard of
care for moderate to severe hypoxic ischemic encephalopathy (HIE). The
treatment ...
Host-microbe interactions in coxsackievirus infection : focus on innate immunity
(2010-05-28)
Coxsackievirus group B (CVB) is a common virus that usually causes only
mild symptoms in humans. However, occasionally these infections result in
severe diseases like meningitis, myocarditis and pancreatitis. In
addition, ...