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Number of siblings and survival from childhood leukaemia : a national register-based cohort study from Sweden
(Cancer Research UKSpringer Nature, 2021-05-31)
Background: Previous studies suggest worse leukaemia survival for children with siblings, but the evidence is sparse, inconsistent and does not consider clinical factors. We explored the associations between number of ...
Impact of commonly prescribed drugs on the risk of colorectal cancer
(2023-11-23)
Colorectal cancer (CRC) stands as the fourth most prevalent cancer worldwide and the third most common in Sweden. Characterized by a protracted progression stage and insidious onset, CRC poses a considerable challenge for ...
Diabetes, metformin and gastric adenocarcinoma
(2021-05-18)
Diabetes may increase the risk and mortality of certain cancers, but its association with gastric adenocarcinoma is not clear. On the other hand, metformin, a first-line treatment for diabetes, may reduce cancer risks and ...
Prediction-driven decision rules, RCT design and survival analysis
(2023-03-23)
Predictions are becoming more and more a part of our lives, and they are becoming increasingly useful in medical science as the science evolves. Increased understanding of disease and its treatments allows us to use ...
Ewing sarcoma : treatment, prognosis and late effects
(2020-04-17)
Ewing sarcoma (ES) is a rare and aggressive childhood/adolescent malignancy which relies on a multidisciplinary treatment approach for cure. The overall survival rate for this young patient group has hardly improved over ...
3D imaging and quantitative analysis of intact tissues and organs
(2020-04-17)
Embryonic development and tumor growth are highly complex and dynamic processes that exist in both time and space. To fully understand the molecular mechanisms that control these processes, it is crucial to study RNA ...
Assessing the importance of rare genetic variants for drug response
(2021-10-27)
Inter-individual variability in drug response is commonly observed in pharmacological treatment, resulting in 40-70% of patients suffering from low drug efficacy or adverse drug reactions. These negative therapeutic effects ...
Characterization of HIV-1 populations in infected cells
(2013-03-21)
Human immunodeficiency virus (HIV) is one of the most fatal diseases in the world today, and the most important worldwide infectious disease in terms of mortality. This virus infects and kills cells of the immune system ...
The male predominance in oesophageal adenocarcinoma and the role of sex hormones
(2023-02-28)
Oesophageal adenocarcinoma is a subtype of oesophageal cancer with rapidly rising incidence over the last decades. This rise in incidence is strongest in western countries and more among men than in women, with a male ...
The role of oestrogens and antibiotics on the development of cancer
(2021-04-29)
Despite advances in cancer treatment and surgery, cancer-related mortality remains the leading cause of death globally, harvesting over ten million lives annually. While the risk factors are both hormonal and non-hormonal, ...