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Role of macrophage receptor MARCO in host defense
(2003-10-31)
Innate immunity, the first line of defense against infectious microorganisms, appeared early in evolution. Innate immunity relies on specialized cells such as macrophages that are the first to encounter pathogens during ...
Evaluation of reverse transcriptase assay for viral load monitoring
(2007-05-17)
Retaining an active reverse transcriptase (RT) enzyme is a fundamental requirement for all retroviruses to replicate. Bearing in mind that HIV has a very high propensity to mutate measuring RT activity to determine the ...
Deciphering HIV genetic variability and evolution by massive parallel pyrosequencing and bioinformatics
(2014-05-05)
HIV-1 is a virus with a very variable genome and therefore has the ability to adapt to new environments which include escape from immune pressure and suboptimal antiretroviral treatment. Next-generation sequencing (NGS), ...
Characterization of HIV-1 populations in infected cells
(2013-03-21)
Human immunodeficiency virus (HIV) is one of the most fatal diseases in the world today, and the most important worldwide infectious disease in terms of mortality. This virus infects and kills cells of the immune system ...
HIV-1 drug resistance and molecular epidemiology in Honduras
(2011-12-28)
The high genetic diversity and rapid evolution of HIV-1 poses a challenge to the worldwide prevention and treatment programs. Effective antiretroviral treatment has significantly improved the quality of life for HIV-infected ...