Search
Now showing items 1-10 of 26
Genetic and environmental aspects of symptomatic gallstone disease
(2009-05-22)
Gallstone disease (GD) represents a major healthcare problem. Gallstones
are likely to result from a complex interaction of the environment and
the effects of multiple undetermined genes.
The aim of this study ...
Prediction of individuals at high absolute risk of esophageal squamous cell carcinoma
(Elsevier, 2020-03-18)
Background and Aims: This study aimed to develop a prediction model for identifying individuals at high absolute risk of esophageal squamous cell carcinoma (ESCC) for endoscopic screening at a curable stage based on readily ...
A community-based child drowning prevention program in Bangladesh : a model for low income countries
(2010-11-25)
Background: Drowning is a global public health problem of children. Children of low- and
middle-income countries are the most susceptible victims. Prevention measures implemented in
high-income countries have effectively ...
Cell interactions in the CNS and their consequences for neuronal apoptosis
(2005-04-21)
The central nervous system consists of an intricate network of neurons and glial cells that depend on reciprocal communication to develop and maintain the vital functions of the brain. if the balance is disturbed by injury ...
Glucocorticoid receptor cross-talk with NF-kappaB and AP-1 : functional role and mechanisms
(2005-03-18)
The protein investigated in this thesis is the glucocorticoid receptor (GR), which is a ligand activated transcription factor that belongs to the superfamily of nuclear hormone receptors. The GR contains three functional ...
The fibrinolytic enzyme system : new markers of potential interest in cardiovascular disease
(2005-12-30)
Impaired fibrinolytic function, mainly due to elevated plasma levels of PAI-1, is a common finding in patients with coronary heart disease. Determination or evaluation of the plasma PAI-1 concentrations are complicated, ...
Ah receptor mediated toxicity : studies in vitro and in a transgenic mouse model
(2007-02-01)
The polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls are ubiquitously present in the environment. Humans are exposed mainly through diet to continuous low levels which on average are in close proximity to ...
Enzymatic studies of alcohol dehydrogenase by a combination of in vitro and in silico methods
(2009-09-04)
The family of alcohol dehydrogenases (ADHs) catalyzes conversions of alcohols, ketons and aldehydes. The early discovery and isolation of ADH (1937) was followed by numerous investigations. It was also the first dimeric ...
Ligand binding and mechanism of microsomal glutathione transferase 1
(2009-01-09)
The homo-trimeric, membrane bound Microsomal Glutathione Transferase 1 (MGST1, EC. 2.5.1.18) belongs functionally to both the glutathione transferase family (GST) and the Membrane Associated Proteins in Eicosanoid and ...
Genetic and epigenetic mechanisms in primary hyperparathyroidism
(2012-12-10)
Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by abnormally excessive secretion of parathyroid hormone (PTH) and elevated serum calcium. PHPT patients can develop a wide range of complications ...