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Detection and epidemiologic subtyping of Legionella pneumophilia using DNA-based molecular methods
(2003-11-14)
Legionella pneumophila causes 2 - 6 % of hospitalised pneumonia cases. Several community- and hospital-acquired outbreaks have been reported over the years. Legionnaires' disease (LD) or legionellosis is also a frequent ...
The effects of endothelin-1 in human adipose tissue
(2010-04-26)
Obesity is a result of an imbalance between energy intake and energy expenditure ending in an excessive accumulation of body fat. Being overweight or obese increases the risk of death because of obesity related complications, ...
Characterization of the mechanisms of action of anticancer agents in vitro and monitoring their effects in vivo
(2005-02-25)
Chemotherapeutic drug resistance is a major clinical problem and cause for failure in the therapy of human cancer. Mutations in apoptotic programs may promote tumour progression and reduce the efficacy of cancer therapy. ...
Art of tumor immunity : extricating hypoxia-driven immunosuppression in the solid tumor microenvironment
(2023-09-20)
The fate of tumors, from initiation to in situ carcinoma and ultimately metastasis, is intricately tied to the balance between the immune system’s effector cytotoxic and tolerogenic immunosuppressive responses, collectively ...
Optimization of suicide gene therapy in stem cell transplantation with special reference to the selection marker OuaSelect
(2009-04-22)
For many patients suffering from leukemia and other hematological malignancies, allogeneic hematopoietic stem cell transplantation (HSCT) represents the only curative approach. However, an optimal HSCT procedure is yet to ...
Microarray gene expression in immunological conditions
(2013-05-15)
The use of microarray techniques for gene expression analysis provides a global view of the transcriptional activity in a biological sample. In this thesis two conditions accompanied by disturbance in the immune system are ...
HCMV-induced epigenetic alterations : a novel pathway to CNS tumors?
(2018-06-01)
Aberrant DNA hypermethylation at CpG islands is a well-established phenomenon involved in transcriptional silencing of tumor suppressor genes. CpG island hypomethylation-mediated reactivation of oncogenes is also documented ...
Appetite control : genetic, immunological and neurobiological aspects
(2017-03-31)
The overall goal of this thesis is to develop a better understanding of the brain’s regulation of appetite, i.e. the hypothalamic regulation of hunger and satiety signals. The correct regulation of appetite is crucial, ...
Aspects of diverting stoma and ERAS in rectal cancer surgery
(2016-04-25)
Annually, nearly 2000 patients are diagnosed with rectal cancer in Sweden. To date, the only known curative treatment is surgery and low anterior resection (LAR) is the operation of choice for tumours in the middle rectum. ...
Oral health and olfactory function : what can they tell us about cognitive ageing?
(2020-04-17)
The objective of this thesis was to advance our understanding of whether oral health and olfactory function may predict accelerated cognitive ageing. Data from two Swedish study populations and one from the United States ...