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Gene dose imbalances in children with mental retardation
(2005-01-14)
Submicroscopic chromosome aberrations can cause mental retardation (MR), congenital malformations and miscarriage. It is difficult to estimate the contribution of cytogenetic abnormalities to MR because of relatively low ...
Evaluation of carbon dioxide insufflation into the open surgical wound : influence on wound temperature, core temperature, and postoperative outcome
(2016-01-22)
Introduction: When the internal organ tissues are abruptly exposed to the relative cold and dry ambient air during open surgery, body heat is lost through radiation, evaporation, and convection. Also general and neuraxial ...
Human colorectal cancer : experimental staging and therapeutics
(2007-04-06)
Colorectal cancer is the third most common cause of death in cancer
worldwide and approximately one million individuals are diagnosed yearly.
Surgery is the primary cure, and if that s not feasible, only palliative
therapy ...
Population and single-cell analysis of human cardiogenesis reveals unique LGR5 ventricular progenitors in embryonic outflow tract
(2021-02-15)
The morphogenetic process of mammalian cardiac development is complex and highly regulated spatiotemporally by multipotent cardiac stem/progenitor cells (CPCs). Mouse studies have been informative for understanding mammalian ...
Biological ageing and kidney transplantation
(2022-05-24)
The aim of this thesis was to investigate the impact of biological ageing in patients with chronic kidney disease, the effect of kidney transplantation on biological ageing and longterm outcome in patients with kidney ...
Anabolic response to amino acid supplementation in critical illness
(2019-11-07)
Background: Critically ill patients suffer from protein catabolism with losses of skeletal muscle and whole-body proteins associated with morbidity and mortality. Catabolism is difficult to overcome, but nutritional ...
Body composition and bone mineral density in rheumatoid arthritis : influence of inflammation and treatment with glucocorticoids and TNF-blocking agents
(2009-11-20)
Rheumatoid arthritis (RA) is a chronic inflammatory disease. Besides symptoms from the joints, changes in body composition and reduced bone mineral are common. Increased fat mass (FM) and loss of muscle mass contribute to ...
Molecular mechanisms of imatinib resistance in gastrointestinal stromal tumor with focus on microRNAs
(2014-12-16)
Gastrointestinal stromal tumor (GIST) is mainly initialized by mutations in receptor tyrosine kinase genes KIT or PDGFRA. The development of imatinib, a small molecule inhibitor that targets these tyrosine kinase receptors, ...
Darier disease : more than skin deep
(2021-10-20)
Darier disease (DD) is a severe, inherited dermatological disorder with a characteristic clinical
and histopathological appearance. It is caused by mutations in the ATP2A2 gene, encoding a
Ca2+ pump in the endoplasmic ...
Hormone-related factors and breast cancer : studies of risk and prognosis
(2006-08-18)
The main purpose of this thesis was to explore the influences of risk factors for breast cancer on breast cancer characteristics and survival.
We evaluated the associations between number and timing of births and ...