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Molecular mechanisms of imatinib resistance in gastrointestinal stromal tumor with focus on microRNAs
(2014-12-16)
Gastrointestinal stromal tumor (GIST) is mainly initialized by mutations in receptor tyrosine kinase genes KIT or PDGFRA. The development of imatinib, a small molecule inhibitor that targets these tyrosine kinase receptors, ...
Bilateral prophylactic mastectomy and immediate breast reconstruction with implants
(2009-11-20)
Bilateral prophylactic mastectomy (BPM) followed by immediate breast reconstruction (IBR) has been more frequently performed over the last 10 years to prevent breast cancer in high-risk women. Since this procedure is ...
Targeting stromal components in the tumor microenvironment for cancer therapy
(2022-12-20)
In the tumor microenvironment (TME), different cell components crosstalk with each other
through various growth factors, cytokines, chemokines, and enzymes. They offered crucial
survival signals for tumor cell proliferation ...
NK cell education and adhesion molecules : implications for immunotherapy
(2016-05-19)
NK cells have a key role in immune surveillance. They detect aberrant expression of stressinduced molecules and MHC class I molecules with an array of activating and inhibitory
receptors. Inhibitory receptors are not only ...