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Weekday of esophageal cancer surgery and its relation to prognosis
(2015-10-02)
In this nationwide Swedish study, later weekday of esophageal cancer surgery entailed increased long-term mortality, particularly for earlier tumor stages. The increase in 5-year mortality for each later weekday was 7% for ...
Passive volume reduction heart surgery using the Acorn CorCap cardiac support device
(2007-09-14)
Heart failure is a growing health problem, affecting an increasing number
of patients with rapidly increasing costs for the health care system. In
spite of recent improvements in pharmacological, non-pharmacological ...
Assessing the toxic impact of chemicals using bacteria
(2004-11-05)
There is a considerable backlog in the testing of new chemical compounds for their ecotoxic properties, mostly due to the lack of appropriate testing methods. In addition, there is a vivid debate today about the test ...
Molecular mechanisms underlying the oncogenic function of SS18 and SSX
(2008-01-04)
The SS18 and SSX genes were initially identified based on their
reoccurrence as fusion partners in synovial sarcoma. As a result of the
specific chromosomal translocation t(X:18), the SS18 gene from chromosome
18 becomes ...
Genomic DNA methylation in health and disease
(2009-01-23)
Cytosine methylation is one of the important epigenetic mechanisms controlling the vertebrate genome. Changes in genomic DNA methylation have been demonstrated in aging, auto-immune diseases and cancer. Aberrant DNA ...
Epigenic regulation and posttranslational modification of human cytochrome P450s : focus on CYP2W1, CYP1A2 and CYP2C18
(2008-11-21)
The cytochrome P450 superfamily represents a very important group of
enzymes that are responsible for the metabolism of drugs as well as of
endogenous compounds. Many P450s are genetically polymorphic causing
important ...
Studies on arachidonic acid metabolism in normal and malignant hematopoietic cells
(2010-01-15)
This thesis deals with the metabolism of arachidonic acid via the 5-lipoxygenase- and the 15-lipoxygenase-1 pathways in normal and malignant hematopoietic cells.
The first part of the thesis (papers I & II) describes ...
HCMV-induced epigenetic alterations : a novel pathway to CNS tumors?
(2018-06-01)
Aberrant DNA hypermethylation at CpG islands is a well-established phenomenon involved in transcriptional silencing of tumor suppressor genes. CpG island hypomethylation-mediated reactivation of oncogenes is also documented ...
On vascular endothelial growth factor B and platelet-derived growth factor C : two members of the VEGF/PDGF family of growth factors
(2001-03-30)
Vascular endothelial growth factors (VEGFs), platelet-derived growth factors (PDGFs) and their receptors are important for normal development. They have also been implicated in many pathological conditions. VEGFs have been ...
Antibiotic resistance and environmental factors : focusing on the situation in Odisha, India
(2012-05-24)
Background: The rise of antibiotic resistant bacteria is a major challenge to global public health. The environment has a significant impact on health and infectious diseases; however, there is a lacuna of information on ...