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Gene regulation mechanisms by the transcriptional coregulator mastermind-like 1
(2009-03-27)
MAML1 was first identified as a coactivator for Notch receptors, but later it was also found to function as a coactivator for several other activators, including p53, beta-catenin, and MEF2C. MAML1 is critical for Notch signalling and has been shown...
Application of metalation reactions for synthesis of sulfur/selenium-containing heterocyclic compounds
(2009-09-25)
convenient synthetic routes toward a wide range of 3-(arylthio)indoles in good yields. In an extension, the sulfonation of 1-(phenylsulfonyl)indoles and pyrroles using chlorosulfonic acid in acetonitrile has been studied, leading to development of a simple...
Immunological studies on anca-associated vasculitis with special reference to T cell activation
(2009-10-16)
on the cell surface expression of thrombospondin-1 (TSP-1) in T cells. The results demonstrate a chemokine-dependent CD26-controlled regulation of T cell polarity and migration through endogenous TSP-1. Based on the results in the third paper we then studied...
Systemic stress response and hyperglycemia after abdominal surgery in rat and man
(2008-10-23)
Surgical trauma results in a complex neuroendocrine and metabolic response known as the systemic stress response, which is initiated by neuronal and humoral signals from the site of the injury. These signals converge at ...
The Rarebit fovea test : a new measure of visual function
(2008-04-23)
Visual acuity (VA) measurement by the use of letter charts is the most
frequently used method for testing foveal function. However, since a
decimal visual acuity of 1.0, often used as limit for normality, can be
achieved ...
Klara, färdiga, gå : om sjuksköterskors kompetens i övergången mellan grundutbildning och yrkesverksamhet
(2009-08-03)
study, the Longitudinal Analyses of Nursing Education (LANE-study). In the present papers, a national cohort of 1,110 nursing students registered in their last (sixth) semester of nursing education in 2002 at 24 educational establishments in Sweden were...
Ultrastructural studies of the blood-urine barrier in proteinuric states
(2010-04-30)
The kidneys filter enormous amounts of blood every day, removing excess fluid and waste products while retaining cells and large proteins in the circulation. The podocytes with their foot processes and slit diaphragms (SD) ...
TGF-beta signaling in carcinogenic transformation of breast epithelial cells, using proteomics
(2008-09-18)
of these cell lines. In a systemic and network analysis, we identified a number of novel TGFbeta-dependent pathways, whose regulation is pivotal for TGFbeta signaling in breast carcinogenesis. We focused on one such pathway (PLAG1-CNK1-RASSF1A) involved...
Studies of histone modification systems in Schizosaccharomyces pombe
(2010-05-26)
), heterochromatin protein Swi6 and cohesin Rad21, which is the cause of lagging chromosomes and defects in chromosome segregation in rpb7-G150D. Analysis of centromeric forward and reverse pre-siRNA transcripts showed accumulation in the dcr1delta mutant. In rpb7-G...
The many faces of IGF-1R from cell surface to the nucleus
(2009-05-01)
The IGF-1R is due to its implication in cancer an intensively studied subject of research. It is well known today that intracellular signals mediated by the IGF-1R play pivotal roles in tumorigenesis and cancer progression. However, the focus has...