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The role of CYP3A4/5 in alprazolam metabolism
(2010-05-14)
Cytochrome P450 3A (CYP3A) enzyme family is involved in the metabolism of about 50 % of all drugs in clinical use. Among CYP3A, CYP3A4 and CYP3A5 are the major enzymes in adults; however CYP3A5 is polymorphic and primarily expressed in black...
Synthetic studies of nitrogen containing heterocycles, particularly pyrazole and benzotriazine derivatives
(2009-11-06)
dihydropyrazolone, namely 4-cyano-1-cyanoacetyl-2-(cyclohexen-1-yl)-1,2-diazaspiro[4.5]decan-3-one, whose structure was confirmed by an X-ray analysis. Mild hydrolysis of this compound resulted in isolation of a des-cyanoacetylated product. In addition, prolonged...
Studies on the phenotype of LXRβ-/- mice : from malabsorption to amyotrophic lateral sclerosis
(2008-10-06)
Liver X Receptors, LXRalpha and LXRbeta (NR1H2) are nuclear receptors
belonging to the superfamily of ligand-activated transcription factors
with a key role in the control of lipid and glucose metabolism. Studies
of the ...
In silico analysis of pathways targeted by EBV infection and malignant transformation
(2009-10-23)
Epstein-Barr virus (EBV) is a ubiquitous γ-herpes virus with dual cell tropism for human B-lymphocytes and epithelial cells. EBV infection is linked to several malignancies such as Burkitt s lymphoma (BL) and nasopharyngeal ...
Transcriptional profiling of the kidney glomerulus
(2010-05-20)
The kidney glomerulus plays a crucial role in ultraltration of the blood through the glomerular capillary wall. Glomerulus injury may occur in many systemic and primary kidney diseases or as secondary eects to drugs and ...
Genome-wide study of HDACs and transcription in Schizosaccharomyces pombe
(2010-05-27)
The eukaryotic genome has to be organized to fit into the cell and this is achieved by packing of DNA into chromatin. The basic repeating structural unit of chromatin is the nucleosome, which consists of DNA wrapped around ...
On histone deacetylases in the epigenetic regulation of neural stem and cancer cell fate
(2008-05-15)
histone proteins H2A, H2B, H3, H4, and 146 base pairs of DNA, wrapped around the histones. In this way, DNA can be tightly packaged in the cell. The N-terminal tails, that protrude out from the histone surfaces can be subjected to different covalent...
From stem cell to neuron : a Sox perspective
(2010-04-30)
in promoting NPCs to commit to a differentiation program leading to the generation of post-mitotic neurons. It is shown that Sox4 and Sox11 act downstream of proneural bHLH proteins and are of critical importance for the activation of neuronal protein...
Characterization of Gcn5 histone acetyltransferase in Schizosaccharomyces pombe
(2009-08-07)
The organisation of eukaryotic DNA into chromatin provides a natural barrier that prevents full access to the DNA thereby inhibiting events such as transcription, replication and repair. In order for these DNA-related ...
Studies of histone modification systems in Schizosaccharomyces pombe
(2010-05-26)
but not H3K4 in vitro. Microarray studies showed increased H3K9me2 in 8,2% of the genes both in promoter and coding regions in the lsd1delta knock-out and 3,8% of the genes also showed increased H3K4me2 in promoter regions. These genes also tend to become...