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Mechanism of pure glucose-dependent insulinotropic activity of a novel imidazoline compound BL11282
(2008-05-01)
We developed a novel, pure glucose-dependent, insulinotropic imidazoline compound, BL11282, which directly affects the insulin exocytotic machinery and does not block the KATP channel activity. BL11282 does not induce ...
Molecular dynamics of protein-nucleic acid complexes
(2010-04-16)
Nucleic acids are essential molecules when it comes to replication, transcription and translation of the genetic information and nearly all functions of nucleic acids are carried out in complex with proteins. The proteins ...
Biomarkers of suicide risk in psychosis
(2009-11-27)
was to investigate the long-term suicide risk in schizophrenia spectrum psychosis, whether concentrations of the CSF monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) are related to suicidal behavior and to the overall mortality...
Biosynthesis and biological role of leukotrienes in human lymphocytes
(2009-04-09)
Leukotrienes (LT) are biologically active metabolites of arachidonic acid. The key enzyme in leukotriene biosynthesis is 5-lipoxygenase (5-LO). Leukotriene B4 exerts its biological effect mainly via BLT1, the high affinity receptor for LTB4...
Transcriptional profiling of the kidney glomerulus
(2010-05-20)
The kidney glomerulus plays a crucial role in ultraltration of the blood through the glomerular capillary wall. Glomerulus injury may occur in many systemic and primary kidney diseases or as secondary eects to drugs and ...
Studies on arachidonic acid metabolism in normal and malignant hematopoietic cells
(2010-01-15)
involved in arachidonic acid metabolism and the capacity to generate leukotriene (LT) B4 via the 5-lipoxygenase pathway in blood tumor cells from patients with precursor B-ALL (acute lymphoblastic leukemia) and AML (acute myeloid leukemia). In addition...
Exhaled nitric oxide in extreme environments
(2009-11-20)
Exhaled nitric oxide (NO) is a useful marker for lower airway inflammation. Since NO was found to be a component of an exhaled breath in the early 1990´s, the Fractional Exhaled Nitric Oxide (FENO 50) measurement is now ...
Calcium signaling : molecular mechanisms and cellular consequences
(2008-11-21)
Cells exploit calcium (Ca2+) signaling to transmit information. In a
multicellular organism, each cell must be able recognize, process, and
respond to information received from the surrounding environment. In this
thesis ...
The Rarebit fovea test : a new measure of visual function
(2008-04-23)
Visual acuity (VA) measurement by the use of letter charts is the most
frequently used method for testing foveal function. However, since a
decimal visual acuity of 1.0, often used as limit for normality, can be
achieved ...
Drug treatment in children with focus on off-label drug use
(2010-08-06)
There is a lack of paediatric documentation concerning efficacy and
safety of many drugs, which contribute to drug use outside the terms of the product license (off-label). In the present thesis, four studies (I-IV), using ...