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Calcium signaling : molecular mechanisms and cellular consequences
(2008-11-21)
Cells exploit calcium (Ca2+) signaling to transmit information. In a
multicellular organism, each cell must be able recognize, process, and
respond to information received from the surrounding environment. In this
thesis ...
Role of genes and environment for the development of rheumatoid arthritis : results from the Swedish EIRA study
(2009-01-09)
Rheumatoid arthritis (RA) is a complex disease with autoimmune features primarily causing destruction in the joints of the body. Knowledge regarding risk indicators and causes are increasing but so far only a few genetic ...
Genetic and environmental influences on endometriosis in Swedish twins
(2016-11-10)
Background: Endometriosis is a common gynecological condition with a substantial economic burden on the society. It is known that both genetic and environmental factors are contributing to the phenotypic development of the ...
Functional characterization of cytosolic and mitochondrial thioredoxin reductases
(2006-09-15)
Mammalian thioredoxin reductases (TrxRs) are homodimeric selenoproteins belonging to the nucleotide oxidoreductase family. They contain a C-terminal penultimate selenocysteine residue, which is kept reduced by the N-terminal ...
Intricate aspects of the thioredoxin system in redox signaling
(2014-05-02)
Reversible modifications of redox sensitive protein thiols by reactive oxygen and nitrogen species have emerged as a major posttranslational mechanism that affects the function of the respective proteins and therewith all ...