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Autocrine and paracrine regulation of Leydig cell survival in the postnatal testis
(2007-09-07)
by immature rats Leydig cells., (ii) possible antiapoptotic effects of IGF-I during testicular development and the role played by IGF-1R in this context; (iii) the influence of IGFBP-3 on apoptosis and steroidogenesis in rat Leydig cells in relation...
Human 15-lipoxygenase-1 and telomerase gene expression in cancer and inflammation
(2008-03-07)
Human 15-lipoxygenase type 1 (15-LOX-1) is an enzyme that catalyzes the oxygenation of free or membrane-bond polyunsaturated fatty acids containing at least one bis-allylic methylene moiety. The enzyme has been proposed to be involved in various...
Tonsillar cancer : incidence, prevalence of HPV and survival
(2008-04-04)
Since human papilloma virus (HPV) in the mid 1980ies was first observed
in squamous cell carcinoma of the head and neck, its role and impact,
especially on oral and oropharyngeal cancer, have attracted extensive
interest. ...
Aspects of immune activation in HIV-1 infection
(2007-05-25)
Abnormal immune system activation is central in HIV-1 pathogenesis leading to CD4+ T-cell depletion and inappropriate immune responses. Disease stage and HIV load strongly correlate with the immune activation level which decreases under...
Modulation of nuclear receptor function by interacting proteins
(2007-08-21)
-modulated factor 1 (PMF-1) and germinal center associated
nuclear protein (GANP) in glucocorticoid signalling.
RIP140 represses ligand activated nuclear receptors, such as GR and LXR.
It is localized in small nuclear foci targeted by a 40 amino acid long
sequence...
Evaluation of reverse transcriptase assay for viral load monitoring
(2007-05-17)
replication has the capacity to eliminate problems associated with divergence, as the virus at all costs must retain an active RT enzyme. We show that two p24 antigen assays utilizing different p24 capture antibodies quantify HIV-1 replication inadequately...
Corticosteroids in advanced cancer : epidemiology, symptom relief and patient experiences
(2007-04-06)
Cortisol is the principal circulating glucocorticoid in man and has a
wide variety of effects in the body. In advanced metastatic cancer,
glucocorticoids are used to alleviate symptoms such as anorexia, poor
strength ...
On the role of HMGB1 and resistin in severe sepsis and septic shock
(2007-12-21)
profiles, and remained elevated up to one week, long after other studied cytokines had returned to low values. For resistin, but not for HMGB1, we could also show significant correlations to disease severity as measured by SOFA and APACHE II scores...
Swedish moist snuff and the risk of cardiovascular diseases
(2007-10-19)
The snuff consumption in Sweden has increased substantially during recent
decades and today more than every fifth male adult uses snuff daily.
However, the evidence on health effects from long-term use of snuff is
limited, ...
Na,K-ATPase as signaling transducer
(2007-11-27)
It is now generally agreed that Na,K-ATPase (NKA), in addition to its
role in the maintenance of Na+ and K+ gradients across the cell membrane,
is a signal transducer. Our group has identified a novel signaling
pathway ...