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Sentinel node based immunotherapy of cancer
(2007-05-25)
The tumor draining lymph node, the sentinel node, is regarded as a valuable station for staging and evaluating prognoses for patients with cancer. The object of this thesis was to investigate the immune response against ...
Repressing the hedgehog signalling pathway
(2007-11-28)
that genetic ablation of Sufu in mice results in embryonic lethality around embryonic day 9 with failure to close the neural tube. Sufu-/- embryos showed high Gli activity that was not repressable at the level of Smo. Sufu+/- mice develop jaw keratocysts and a...
Autocrine and paracrine regulation of Leydig cell survival in the postnatal testis
(2007-09-07)
The primary function of testicular Leydig cells is the production of androgens that promote sexual differentiation in the fetus, secondary sexual maturation at the. time of puberty, and spermatogenesis in the adult. ...
B-cell survival factors in multiple sclerosis and myasthenia gravis
(2007-03-14)
Multiple sclerosis (MS) is a chronic, progressive neurological disease in which death of myelin-producing oligodendrocytes and axonal damage are prominent pathological features. The cause of MS is unknown but genetic and ...
Modulation of nuclear receptor function by interacting proteins
(2007-08-21)
Nuclear receptors are a family of transcription factors involved in many
biological processes. They represent key potentials as therapeutic
targets for several clinical conditions such as diabetes, obesity,
cardiovascular ...
Asthenopia in schoolchildren
(2007-05-11)
Asthenopia is a term used to describe different symptoms associated with the use of the eyes, such as pain, blurred vision, diplopia, headaches. Asthenopia is most often reported in association with near vision. Children ...
Analysis of kidney glomerular and microvascular transcriptomes
(2007-09-21)
Kidney glomeruli play a crucial role in the maintenance of body homeostasis. Many diseases attack the kidney function by primarily affecting glomeruli. However, the transcriptome profiles and the function of the glomerulus ...
Endothelin receptor antagonism and hypertonic solutions in experimental endotoxin shock
(2007-05-18)
Sepsis is a common and serious condition among patients in the intensive care unit. It is characterized by a systemic inflammatory response, resulting in cardiovascular instability and impaired organ tissue oxygenation due ...
Swedish moist snuff and the risk of cardiovascular diseases
(2007-10-19)
The snuff consumption in Sweden has increased substantially during recent
decades and today more than every fifth male adult uses snuff daily.
However, the evidence on health effects from long-term use of snuff is
limited, ...
Studies on the phenotype and function of osteoclasts using osteopetrotic and rachitic animal models
(2007-09-07)
acidification leads to dissolution of mineral, and secretion of
proteolytic enzymes e.g. cathepsin K (Ctsk) and matrix metalloproteinase
(MMP)-9 completes degradation of the exposed collagen. Another secreted
osteoclast enzyme, tartrate-resistant acid...