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Mdm2 phosphorylations : characterization and applications
(2007-09-07)
Cancer is a widespread disease. In spite of all research resulting in new
improved therapies, there are still many tumors that cannot be cured. To
oppose that, also a preventive research approach is important with ...
Aspects of immune activation in HIV-1 infection
(2007-05-25)
Abnormal immune system activation is central in HIV-1 pathogenesis leading to CD4+ T-cell depletion and inappropriate immune responses. Disease stage and HIV load strongly correlate with the immune activation level which decreases under...
Human 15-lipoxygenase-1 and telomerase gene expression in cancer and inflammation
(2008-03-07)
Human 15-lipoxygenase type 1 (15-LOX-1) is an enzyme that catalyzes the oxygenation of free or membrane-bond polyunsaturated fatty acids containing at least one bis-allylic methylene moiety. The enzyme has been proposed to be involved in various...
The p53 pathway : role of telomerase and identification of novel targets : acts of a master regulator of tumor suppression
(2007-05-17)
A key role of the p53 protein in tumor suppression is reflected by its
frequent mutations in human tumors. p53 is activated by various types
stress conditions such as DNA damage, hypoxia and oncogene activation
that ...
Studies on human sterol 27-hydroxylase with emphasis on its mechanism of regulation and metabolic consequences of a deficient enzyme
(2007-05-11)
Sterol 27-hydroxylase (CYP27A1) is a mitochondrial cytochrome P-450
enzyme present in most animal cells. In hepatocytes, CYP27A1 has an
important role in connection with biosynthesis of bile acids from
cholesterol. In ...
Transcriptional and post-transcriptional regulation of telomerase reverse transcriptase (hTERT) expression : the role of histone modification and alternative splicing
(2008-01-18)
Telomerase, an RNA-dependent DNA polymerase responsible for telomeric DNA
elongation, is silent in most normal differentiated human cells due to
the tight repression of its catalytic unit, telomerase reverse
transcriptase ...
Toxicological studies of opiate-related death
(2007-04-25)
This thesis comprises studies on opiate overdose death, and focuses on
evaluation of toxicological characteristics including the possible
influence of abstinence and polydrug use for the fatal outcome.
In order to ...
Regulation and characterization of antimicrobial peptides in man and mice
(2007-09-07)
The gene-encoded antimicrobial peptides have emerged as an important
component of innate immunity. In mammals, antimicrobial peptides are
either directly secreted from cells or found in cell granules, which can
be ...
Regulation of insulin-like growth factor-1 receptor expression and signaling
(2007-05-25)
Insulin-like growth factor-1 receptor (IGF-1R), a member of the insulin
receptor tyrosine kinase family is a broadly expressed transmembrane
receptor that plays a key role in malignant cell growth. IGF-1R transmits
information provided...
Transcriptional regulation by inner nuclear membrane proteins
(2007-04-19)
, bind promoters of SPS-sensor regulated genes and induce their transcription. Recessive loss-of-function mutations in ASI1, ASI2 and ASI3 (amino acid sensor independent) genes bypass the requirement of a functional SPS-sensor and constitutively induce...