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Endothelin and the regulation of peripheral and uteroplacental vascular tone during pregnancy
(2004-11-26)
endothelin in the regulation of basal vascular tone and the sensitivity to ET-1 was investigated by forearm plethysmography. The sensitivity to ET-1 was unaltered during normal pregnancy, whereas it was decreased in PE. There was an attenuation of endogenous...
Family history and breast cancer susceptibility : clinical and molecular studies
(2006-09-15)
with a more modest increased risk of the disease. Mutations in the known high risk genes BRCA1, BRCA2 and p53 account for less than 25% of the familial risk for breast cancer, while the remainder remain genetically unexplained despite a large effort...
Population structure and antibiotic resistance of the genus enterococcus in humans, animals and the environment
(2005-11-18)
the prevalence of antibiotic resistant enterococci in these samples. In a European study, 17,157 enterococcal isolates from 2,868 samples from humans, animals and the environment in Sweden, Denmark, the United Kingdom, and Spain were studied (study I...
The post-polio syndrome : studies of immunology and immunomodulatory intervention
(2005-09-02)
Late effects in patients with prior poliomyelitis were first reported in the nineteenth century and have been referred to as the post-polio syndrome (PPS). PPS is characterized by new muscular deterioration, fatigue and ...
Immersion and recreational boating-related injuries in Alaska
(2005-11-04)
Background: Cold water is an ever-present hazard in Alaska, and when water-related injuries occur, they often take place in remote environments, where the nearest trained emergency response teams are several hours away. ...
Nephrin-mutations in congenital nephrotic syndrome of the Finnish type and cell lineage specific gene regulation
(2005-04-21)
of kidney and brain specific regulatory elements in the region -4 kb; -2.1 kb (where the first nucleotide of the ATG codon of nephrin is +1). The sequence between -1.9 and -1.2 kb was found to be important for spinal cord and pancreas expression...
Hormonal and paracrine influences on Leydig cell steroidogenesis
(2006-08-18)
evoked by two stimulators of steroidogenesis, hCG and the pro-inflammatory cytokine IL-1α were investigated. Both hCG and IL-1α activated the extracellular signal-regulated kinases 1 and 2 (ERK1/2) in primary cultures of immature rat Leydig cells...
Functional studies on the interaction of immunoglobulins with HIV-2 envelope
(2005-09-16)
Infection with HIV-2 has a much more limited geographic distribution than HIV-1, being less readily transmitted and is generally less pathogenic. The role of immunoglobulins in defence against pathogens in different body compartments is known, where...
Studies on alcoholic liver disease
(2006-11-17)
of alcohol related liver disease. We found that rats had appearance of IgG against rat CYP3A 1 and CYP2E 1 during chronic ethanol feeding We found that patients had reactivity against CYP3A4 and CYP2E I in about 20 to 30% and 10 to 20% of the alcoholic sera...
Orthology and protein domain architecture evolution
(2006-05-22)
A major factor behind protein evolution is the ability of proteins to evolve new domain architectures that encode new functions. Protein domains are widely considered to constitute the "atoms" of protein chains, acting as ...