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Nephrin-mutations in congenital nephrotic syndrome of the Finnish type and cell lineage specific gene regulation
(2005-04-21)
Kidneys, the main excretory organs in vertebrates, play central role in removing water soluble metabolic waste products from the organism. Many acquired and inherited renal diseases in man lead to kidney dysfunction and ...
Kinetics of HIV-1 drug resistance mutations in vivo
(2006-03-10)
Antiretroviral therapy (ARV) exert a selective pressure on HIV-1 and may select viral drug resistant strains which have competitive advantage in the presence of the drug. Knowledge about the appearance and disappearance ...
Human 15-lipoxygenase-1 and telomerase gene expression in cancer and inflammation
(2008-03-07)
Human 15-lipoxygenase type 1 (15-LOX-1) is an enzyme that catalyzes the oxygenation of free or membrane-bond polyunsaturated fatty acids containing at least one bis-allylic methylene moiety. The enzyme has been proposed ...
On angiogenesis modulation
(2009-08-28)
During evolution, the transition from unicellular to multicellular organisms required the origin of a transport system capable of interconnecting specialized cells throughout the body of the organism. In higher animals, ...
Regulation of the ribosomal RNA transcription by c-MYC oncoprotein
(2006-11-30)
The transcription factor c-Myc is a key regulator of growth and proliferation. c-Myc levels are tightly controlled and deregulated c-Myc is often associated with human cancers. In our initial studies we observed that upon ...
Rapid detection of drug resistance and genetic characterisation of Mycobacterium tuberculosis isolates in Honduras
(2010-12-17)
Background: New challenges for tuberculosis (TB) control are emerging in the 21st century. The deadly combination TB/HIV as well as the development and spread of new forms of drug resistance are some examples. In this ...
Improved human papillomavirus DNA typing methods and biology of cervival cancer
(2006-05-19)
Cervical cancer is the second most common cancer among women worldwide. Persistent HPV has been identified as a main risk factor in cervical cancer development. Oncoproteins E6 and E7 of highrisk HPV interact with cellular ...
Evaluation of function in individuals with knee osteoarthritis
(2017-09-27)
Introduction: Osteoarthritis, the most common joint disease, results in joint pain and limited function. In clinical practice, the array of measurements used to evaluate function are generally restricted to patient-reported ...
Lactate determination in ante- and intrapartum surveillance
(2007-05-11)
Lactate concentration is reported to be high in amniotic fluid (AF).
Prelabour rupture of membranes (PROM) occur in about 20% of all
pregnancies. The condition is associated with fetal and maternal
complications, and might ...