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Family history and breast cancer susceptibility : clinical and molecular studies
(2006-09-15)
Apart from gender, family history is the most important risk factor for breast cancer. In 5-10 % of the cases there is a family history pattern of an autosomal dominant disease and there is also a familial clustering of ...
Cellular and network mechanisms in neurodegenerative disorders : neurotoxicity and rescue strategies
(2018-05-17)
The brain can be described as a complex network and its functioning depends on an efficient communication between all its components. Large-scale communication is made possible by neuronal-network oscillations. Oscillations ...
Alzheimer disease associated Abeta and gamma-secretase : mitochondrial localization and involvement in cell death
(2009-01-30)
In several neurodegenerative disorders, including Alzheimer disease (AD)
and Parkinson disease (PD), protein aggregation is accompanied by
mitochondrial dysfunction. An increasing number of proteins found in
mitochondria ...
Congenital adrenal hyperplasia, cyp21a2 deficiency : clinical and physiological aspects of pregnancy, screening and growth
(2013-10-18)
The subjects dealt with in this thesis are clinical aspects of congenital adrenal hyperplasia (CAH), such as neonatal screening, growth and the incidence of CAH during the last century in Sweden. In addition, we have used ...
Amyloid precursor protein with the Alzheimer´s disease 670/671 mutation : animal and cellular models
(2008-10-03)
The amyloid precursor protein (APP) and it s derivatives play a key role
in the pathogenesis of Alzheimer s disease (AD), which is characterized
by the presence of multiple aggregates of an APP proteolytic product, ...