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Estrogen effects on different neurotransmitters in rat hippocampus : implications for cognitive function
(2004-11-12)
. Ovariectomy severely
impaired reference memory and increased MK-801 binding in the
hippocampus. Estradiol treatment improved memory performance and reduced
MK-801 binding back to normal level.
The studies presented here provide insights into some mechanisms...
Studies on vascular remodeling in acute coronary artery disease
(2005-08-26)
Atherosclerosis is an arterial disease, characterized by endothelial dysfunction, vascular inflammation, and lipid accumulation in the vessel wall. Unstable coronary syndroms may be initiated by rupture of the atherosclerotic ...
Biophysical studies on aggregation processes and amyloid fibrils with focus on Alzheimer's disease
(2004-08-13)
Alzheimer's disease (AD) is a fatal neurodegenerative disease, and is the most common form of dementia, affecting 1-2% of the population in industrialized countries. It is believed that intermediate species formed during ...
Early oncogenic events and defective apoptosis in prostate cancer
(2005-03-18)
Prostate cancer is one of the most common malignancies in males in the Western world. Although the mechanisms are unclear, it is generally believed that the accumulation of genetic alterations leads to the tumor formation. ...
Standardization and application of quantitative PCR methods in patients with hematological malignancies
(2004-10-29)
was found in 72% of samples. However, if a cutoff level of 0.01% was applied, the concordance was 89%.
Application of RQ-PCR techniques gains quantitative information on DNA and mRNA levels, and so we applied this approach to investigate cytokine m...
On the role of NMDA receptor subunits in the acute and chronic effects of nicotine
(2005-03-18)
Nicotine is considered the main dependence-producing constituent in tobacco products. In analogy with other drugs of abuse, nicotine enhances dopamine (DA) neurotransmission within the mesocorticolimbic DA system. This ...
Risk factors for haematological malignancies : immune-mediated diseases, body mass index and magnetic fields
(2006-11-03)
Haematological malignancies constitute approximately 7% of all cancer cases in Sweden, and leukaemia is in fact the most common malignancy among children. The few established risk factors, such as ionising radiation and ...
Genomic clues to secondary injury mechanisms in brain trauma
(2006-09-01)
Traumatic brain injury (TBI) is a heterogenous disease that can lead to persistent disability or death. The immediate mechanical disruption of brain tissue is followed by a phase of secondary brain injury. During this phase ...
Characterization of hippocampal slice cultures as model systems for neurodegenerative processes in Alzheimer's disease
(2005-11-04)
Alzheimer's disease (AD) is the most common cause of dementia and a
growing health care problem worldwide. The disease affects different
brain regions, including hippocampus, enthorhinal cortex, amygdala,
neocortex and ...
Occupational exposure to pesticides and risk of leukemia among offspring in Costa Rica
(2006-11-03)
assessment models (Paper III). Associations between parental exposure to pesticides and the risk of leukemia in the offspring were examined in a population-based case-control study in Costa Rica. All cases of childhood leukemia (N=334), ages 0-14 at diagnosis...