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Early oncogenic events and defective apoptosis in prostate cancer
(2005-03-18)
Prostate cancer is one of the most common malignancies in males in the Western world. Although the mechanisms are unclear, it is generally believed that the accumulation of genetic alterations leads to the tumor formation. ...
Methodological studies applying new techniques for evaluation of arterial function
(2014-09-26)
Atherosclerotic cardiovascular disease is the most common cause of death in the Western world today. Atherosclerosis in the arterial wall is related to aging and the inflammatory and calcification processes, and is influenced ...
Antimicrobial peptides and proteins in innate immunity : emphasis on isolation, characterization and gene regulation
(2005-03-18)
Antimicrobial peptides are endogenous antibiotics and effector molecules
of Innate immunity. These peptides are mainly localised to epithelial
linings and circulating neutrophils. They kill microbes by disruption of
their ...
Host-pathogen interactions in severe group A streptococcal infections
(2007-12-28)
Streptococcus pyogenes, also called group A Streptococcus (GAS), is an important human pathogen ranked number 9 on the list of global killer pathogens. It causes a wide spectrum of disease, including uncomplicated superficial ...
Eosinophilic dermatosis implications of skin-commensal bacteria and antimicrobial peptides and proteins at birth
(2009-08-28)
At birth, the newborn infant is transferred from a sterile life in utero to an earthly life in coexistence with microbes. This transition includes the potential danger of a microbial invasion through the epithelial linings, ...
Leukocyte activation in newborns in relation to prenatal stress
(2009-11-05)
The aim of this project is to describe the pattern of innate immunity responses at birth with focus on the recruitment of leukocytes such as eosinophils and neutrophils and their content of cathelicidin antimicrobial peptide ...
Studies of the role of the cathelicidin peptide LL-37 in epithelial biology
(2010-05-14)
The biology of epithelial immunity as well as of tissue repair is complex and highly regulated. A variety of molecules, cell types, and biological processes such as, cell differentiation, proliferation and migration, ...
Oral mucositis and periodontal disease in patients with primary or acquired immunodeficiencies
(2013-09-11)
The infection and inflammation in the oral cavity are commonly related to the skewed interaction between host immunity and inhabiting microorganisms. Both primary and acquired immunodeficiency conditions are frequently ...
Expression and regulation of antimicrobial peptides in mucosal immunity
(2012-10-25)
Antimicrobial polypeptides (AMPs) are effector molecules of the innate immune defense. AMPs are mainly expressed in epithelial cells and immune cells, providing the first line of defense to infection as direct antimicrobials. ...
Primary hyperparathyroidism : comorbidity and outcome after parathyroid adenomectomy
(2013-05-20)
Primary hyperparathyroidism (pHPT) is associated with increased mortality in certain malignant tumours. Breast cancer is the most common and a shared aetiology has been suggested. In a register-based nested case-control ...