Search
Now showing items 1-10 of 71
Cryo-electron tomography of individual protein molecules
(2005-08-29)
Averaging methods of determining structure, such as X-ray diffraction, do not preserve information about the flexibility of molecules. Cryo-electron tomography allows us to reconstruct individual hydrated objects. The ...
Studies of cellular pathogenesis in experimental autoimmune encephalomyelitis
(2004-08-20)
In this thesis, I have studied antigen-specific therapeutic interventions
of experimental autoimmune encephalomyelitis (EAE) and aimed to
understand the respective roles of different cell subsets in initiation
and ...
Endometrial, embryonic and ovarian aspects of human implantation
(2006-05-11)
with T4 resulted in increased concentration of ERK1/2 (activation of TR receptors). Real-time PCR did not show significant changes in the expression of glucose transporter1 and estrogen receptors (ER) alpha in endometrial cells or ERbeta genes in ovarian...
Hormonal mechanisms of menstrual disturbances, metabolic disorders and effects of oral contraceptives in female athletes
(2004-11-12)
Background: During the last decades the number of women participating in sports has increased dramatically. Although exercise has beneficial health effects for most of these women, we now realize that strenuous exercise ...
In vivo quantification of extrastriatal dopamine D2 receptors in the human brain
(2005-03-25)
The dopamine D2 receptor subtype attracts considerable attention in research on the patophysiology and drug treatment of several neuropsychiatric disorders, such as schizophrenia and Parkinson's disease. The brain imaging ...
Tobacco smoking and periodontal health in a Saudi Arabian population
(2005-09-23)
of periodontal bone loss of more than 30% of the root length was 3.5-fold and 4.3-fold elevated in water pipe and cigarette smokers, respectively, compared to non-smokers (p < 0.01). The relative risk associated with heavy smoking was 7.5-fold elevated in water...
Platelets and eosinophils in lung tissue remodelling
(2006-08-25)
Tissue injury and inflammation followed by effective repair restores normal function, but defective repair with associated tissue remodelling and fibrosis can lead to loss of organ function. Thus, interactions between ...
Chromatin structure and histone modifications in gene regulation
(2006-11-24)
In the living cell, DNA is densely packed into a chromatin structure constituting nucleosomal arrays. One nucleosome core particle includes a disc shaped protein octamer consisting of pairs of histones H2A, H2B, H3 and H4. 146 bp of DNA is wrapped...
Risk factors for haematological malignancies : immune-mediated diseases, body mass index and magnetic fields
(2006-11-03)
Haematological malignancies constitute approximately 7% of all cancer cases in Sweden, and leukaemia is in fact the most common malignancy among children. The few established risk factors, such as ionising radiation and ...
HIV-2 genetic evolution and viral dynamics
(2006-05-03)
to CXCR4 using virus during disease progression. We did not see a clear pattern of neutralization escape as is seen in HIV-1. We saw a pattern of changes in the number of potential N-linked glycosylation sites during disease progression. HIV-2 has fewer...