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Born too small or too early : effects on blood pressure, renal function and retinal vascularization in adulthood : experimental and clinical studies
(2004-11-12)
or normal birth weight controls. In these subjects, we also aimed
to characterize the morphology of the retinal arterioles and certain
biochemical serum markers.
Material and methods: Pregnant rats were given DEX from day 1. Their
off-springs were...
The metabolic syndrome : studies on thrifty genes
(2004-09-25)
and their dysfunction might be associated with increased
muscle lipid accumulation and insulin resistance. The relative
contribution of the two glucose transport proteins GLUT1 and GLUT4 was
studied by using a novel photolabeling technique in primary cultures of
human...
Adult human neural stem cells : properties in vitro and as xenografts in the spinal cord
(2005-05-27)
Though the presence of stem cells in the adult human brain has been
presented earlier, much has yet to be discovered about these cells.
However, the mere potential of these cells has had a significant impact
of how we ...
The fibrinolytic enzyme system : new markers of potential interest in cardiovascular disease
(2005-12-30)
Impaired fibrinolytic function, mainly due to elevated plasma levels of PAI-1, is a common finding in patients with coronary heart disease. Determination or evaluation of the plasma PAI-1 concentrations are complicated, due to a natural variation...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Regulation of signal transduction in the striatum by typical and atypical antipsychotic drugs
(2005-05-13)
), thereby amplifying cAMP/PKA-mediated responses. Haloperidol also stimulates the phosphorylation of the two mitogen-activated protein kinases (MAPK), extracellular signal-regulated kinases 1 and 2 (Erk1/2). In addition, haloperidol phosphorylates...
Immunogenicity of and apoptosis modulation by Epstein-Barr virus (EBV)-encoded latent membrane protein-1 (LMP1) : implications for nasopharyngeal carcinoma
(2005-05-19)
which enable the virus to efficiently immortalize B lymphocyte and also transform cells of other types. Among the viral genetic products, a membrane integral latent infection protein, latent membrane protein-1 (LMP1) is of particular interest, since...
Mechanisms of resistance to ciprofloxacin in Neisseria gonorrhoeae
(2006-04-07)
. 125 - 0.25 mg/L. Introduction of alterations in major outer membrane porin, PorB1b, and probably other alterations, in a moderately ciprofloxacin resistant strain (MIC 0.25 mg/L) gave transformants with MICs of ciprofloxacin 0.5-16 mg/L. In one...
Environmental factors and p53 mutation spectrum in lung cancer
(2006-05-19)
those exposed during the early years of operations, when emissions were high, and for less than 20 years, odds ratio (OR) 2.5, 95% confidence interval (CI) 0.9-7.1, compared to unexposed. In total, we detected 103 mutations in 99 lung tumors (mutation...
The post-polio syndrome : studies of immunology and immunomodulatory intervention
(2005-09-02)
Late effects in patients with prior poliomyelitis were first reported in the nineteenth century and have been referred to as the post-polio syndrome (PPS). PPS is characterized by new muscular deterioration, fatigue and ...