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Environmental factors and p53 mutation spectrum in lung cancer
(2006-05-19)
The use of molecular biomarkers, such as mutations in the p53 gene, has raised expectations for improving the resolution power in epidemiological studies. In this thesis we assessed the influence of smoking, environmental ...
Genetic and epidemiological studies of dystocia : difficult labour
(2008-12-19)
Objective: To explore the epidemiological characteristics, the influence
on reproductive health and the genetic basis of dystocia prolonged and
difficult labour.
Material and methods: The thesis has a retrospective ...
Characterization of the Alzheimer's disease-associated clac protein
(2005-03-18)
Alzheimer's disease (AD) is the most prevalent form of dementia in
elderly people and is neuropathologically characterized by the presence
of extracellular senile plaques (SPs) in the brain. SPs are mainly
composed of ...
Exposure to air pollution in the work and residential environment during pregnancy and adverse birth effects
(2019-10-17)
Air pollution is an environmental health risk that causes millions of premature deaths every year around the world. Air pollution exposure has been associated with respiratory and cardiovascular morbidity and an increased ...
The role of telomerase reverse transcriptase in human malignancies : genetic polymorphisms and promoter mutations
(2017-09-15)
Telomerase is a ribonucleoprotein with its catalytic subunit telomerase reverse transcriptase (TERT) as a key component, lengthening telomeres. In differentiated human cells, telomerase is silent due to the transcriptional ...
Telomeres and telomerase and their functional applications in myeloproliferative neoplasms and acute myeloid leukemia
(2016-10-25)
Myeloproliferative neoplasms (MPNs) are a group of diseases characterized by hyperproliferation in the myeloid lineages of the bone marrow, leading to increased levels of circulating mature blood cells from one or more ...
On functions of neurotrophic factors in taste buds and teeth
(2017-11-24)
Background: Chemosensory disorders affect approximately 15% of the U.S. population and an estimated 200,000 individuals visit a doctor each year for problems with their ability to taste or smell (NIDCD). Among the common ...